重组Anti-MLLT11抗体[CHCR115] (ab109016)
![Western blot - Anti-MLLT11 antibody [CHCR115] (ab109016)](https://www.abcam.cn/ps/products/109/ab109016/Images/ab109016-121589-anti-mllt11-antibody-chcr115-western-blot.jpg "Western blot - Anti-MLLT11 antibody [CHCR115] (ab109016)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [CHCR115] to MLLT11
- Suitable for: WB, IHC-P
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-MLLT11抗体[CHCR115]
参阅全部 MLLT11 一抗 -
描述
兔单克隆抗体[CHCR115] to MLLT11 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details
不适用于: Flow Cyt or IP -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Jurkat, K562 and Molt-4 cell lysates; Human thymus tissue
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
CHCR115 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109016于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 10 kDa.
|
|
| IHC-P | (2) |
1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
|
| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 10 kDa. |
|
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
应用说明
Is unsuitable for Flow Cyt or IP.
靶标
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组织特异性
Highly expressed in thymus and all leukemic cell lines. -
疾病相关
A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1. -
序列相似性
Belongs to the MLLT11 family. - Information by UniProt
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数据库链接
- Entrez Gene: 10962 Human
- Omim: 604684 Human
- SwissProt: Q13015 Human
- Unigene: 75823 Human
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别名
- AF1Q antibody
- AF1Q_HUMAN antibody
- ALL1 fused gene from chromosome 1q antibody
see all
图片
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Western blot - Anti-MLLT11 antibody [CHCR115] (ab109016)All lanes : Anti-MLLT11 antibody [CHCR115] (ab109016) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : K562 cell lysate
Lane 3 : Molt4 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 10 kDa -
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MLLT11 antibody [CHCR115] (ab109016)](https://www.abcam.cn/ps/products/109/ab109016/Images/ab109016-121588-anti-mllt11-antibody-chcr115-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MLLT11 antibody [CHCR115] (ab109016)Immunohistochemical analysis of MLLT11 expression in paraffin-embedded Human thymus tissue using ab109016 at 1/100 dilution.
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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![Anti-MLLT11 antibody [CHCR115] (ab109016)](https://www.abcam.cn/ps/products/109/ab109016/Images/ab109016-3-benefits-of-recombinant-antibodies.png)
Anti-MLLT11 antibody [CHCR115] (ab109016)
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab109016 被引用在 5 文献中.
- Chen L et al. Identification of the novel prognostic biomarker, MLLT11, reveals its relationship with immune checkpoint markers in glioma. Front Oncol 12:889351 (2022). PubMed: 36033495
- Duan N et al. A naturally derived small molecule PSM0537 targets the AF1Q-TCF4 interaction to suppress COX2 expression and inhibit cell proliferation and metastasis in osteosarcoma. Am J Cancer Res 11:2637-2653 (2021). PubMed: 34249419
- Huang S et al. BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Front Cell Neurosci 13:523 (2019). PubMed: 31849612
- Gruber ES et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 8:N/A (2019). PubMed: 31671695
- Jin H et al. MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer. Mol Ther Nucleic Acids 11:312-322 (2018). PubMed: 29858066