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AB308167

重组Anti-Miz1抗体[HL1548]

Anti-Miz1 antibody [HL1548]

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Rabbit Recombinant Monoclonal Miz1 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZBTB17.

查看别名

MIZ1, ZNF151, ZNF60, ZBTB17, Zinc finger and BTB domain-containing protein 17, Myc-interacting zinc finger protein 1, Zinc finger protein 151, Zinc finger protein 60, Miz-1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Miz1 antibody [HL1548] (AB308167)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Miz1 antibody [HL1548] (AB308167)

Immunofluorescent analysis of 4% paraformaldehyde-fixed U2OS cells labeling Miz1 with ab308167 at 1/500 dilution. Green : Miz1 stained by Miz1 antibody [HL1548] (ab308167) diluted at 1 : 500. Red : alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody diluted at 1 : 1000.

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

HL1548

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human ZBTB17. The exact immunogen used to generate this antibody is proprietary information.

Q13105

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搭配使用产品

Sample Prep & Detection Kits

AB201798

DyLight® 405 Conjugation Kit (Fast) - Lightning-Link®

Schematic Diagram - DyLight® 405 Conjugation Kit (Fast) - Lightning-Link® (AB201798)

  • 0
  • 0
Sample Prep & Detection Kits

AB154873

Gold Conjugation Kit (40nm, 20 OD)

Conjugation - Gold Conjugation Kit (40nm, 20 OD) (AB154873)

  • 0
  • 0
Primary Antibodies

AB79055

Anti-MDA5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MDA5 antibody (AB79055)

  • 4
  • 1
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

KD Validated|RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Proteins & Peptides

AB151354

Recombinant Human Miz1 protein

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" } } }
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产品详情

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Miz1 also known as Zinc finger Miz1 is a transcription factor with a mass of around 87 kDa. It features multiple zinc finger domains allowing it to bind DNA directly. Miz1 is widely expressed in various tissues particularly in the nucleus of cells. Its function includes both activating and repressing gene transcription depending on the context. By modulating transcription Miz1 plays a critical role in cellular proliferation and differentiation.
Biological function summary

Miz1 interacts with other transcription factors and forms part of larger complexes that influence the expression of genes involved in cell cycle regulation. Frequently Miz1 associates with the Myc protein which modifies its activity allowing for tight control over its function. Through these interactions Miz1 regulates important genes that can tip the balance between cell survival and apoptosis.

Pathways

The function of Miz1 integrates into the TGF-beta and MAPK signaling pathways. In the TGF-beta pathway Miz1 collaborates with Smads to regulate target genes that govern cell growth. Meanwhile in the MAPK pathway Miz1's interaction with Myc influences gene expression impacting cellular responses to external signals. These pathways support Miz1's role in controlling cell proliferation and stress responses.

Miz1 demonstrates significant involvement in cancer and developmental disorders. Dysregulation of Miz1 can lead to uncontrolled cell proliferation contributing to oncogenesis. Miz1's interaction with Myc is particularly linked to its oncogenic potential affecting genes that drive tumor progression. Additionally mutations or alterations in Miz1 function can impact developmental processes suggesting its role in some congenital conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed : 25245946).
See full target information ZBTB17
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Abcam Product Promise

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