AB167197

Anti-MIIP抗体

Name: MIIP抗体 (ab167197)| Abcam中文官网
Brand: Abcam Limited
SKU: AB167197
Price: 4560 CNY
Availability: InStock

Anti-MIIP antibody

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(2 Publications)

Mouse Polyclonal MIIP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MIIP.

查看别名

IIP45, MIIP, Migration and invasion-inhibitory protein, IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45

1 Images

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Western blot - Anti-MIIP antibody (AB167197)

All lanes:

Western blot - Anti-MIIP antibody (ab167197) at 1 µg/mL

Lane 1:

Lysate of 293T cells transfected with MIIP at 15 µL

Lane 2:

Lysate of 293T cells (non-transfected) at 15 µL

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 43 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human MIIP.

Q5JXC2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MIIP also known as Migration and Invasion Inhibitory Protein is a protein with a mass of approximately 47 kDa. It acts mechanically as an important regulator of cellular movement and invasion processes. MIIP expression occurs in various tissues including the brain and reproductive organs. Scientists recognize MIIP for its role in modulating cytoskeletal dynamics and protein interactions that affect cell motility.

Biological function summary

MIIP plays a significant role in inhibiting cell migration and invasion contributing to its function as a tumor suppressor. It interacts with important components of the cytoskeletal network and may work together with other proteins to form complexes that stabilize actin filaments. Through these interactions MIIP helps control cellular structure integrity and movement impacting the invasive potential of cells.

Pathways

MIIP impacts several key signaling pathways. It integrates into the PI3K/AKT signaling pathway which influences cell survival and proliferation. This protein also interacts within the Wnt/β-catenin pathway known for its role in cell growth and development. MIIP's association with these pathways links it to interactions with proteins like AKT and β-catenin creating a regulatory network that balances normal and pathological cell behavior.

MIIP is associated with cancer and its progression. Studies have shown that reduced MIIP expression correlates with increased tumor invasiveness and metastasis particularly in gliomas and breast cancer. In these contexts MIIP interacts with proteins such as matrix metalloproteinases (MMPs) which aid in tissue invasion. By inhibiting these interactions MIIP exerts a protective effect against tumor progression highlighting its potential as a therapeutic target.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.

See full target information MIIP

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 6:1059 PubMed37853052

2023

Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyang Zhang,Yubo Zhao,Xiaobai Liu,Xuelei Ruan,Ping Wang,Libo Liu,Di Wang,Weiwei Dong,Chunqing Yang,Yixue Xue

Oncology reports 41:1113-1121 PubMed30431104

2018

Long non‑coding RNA MALAT1 correlates with cell viability and mobility by targeting miR‑22‑3p in renal cell carcinoma via the PI3K/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong Li,Zhiqiang Ma,Xiangdong Xu

View all publications

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Anti-MIIP抗体

Anti-MIIP antibody

Western blot - Anti-MIIP antibody (AB167197)