Anti-Mib1/Mindbomb抗体(ab74134)
Key features and details
- Rabbit polyclonal to Mib1/Mindbomb
- Suitable for: WB
- Reacts with: Drosophila melanogaster
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-Mib1/Mindbomb抗体
参阅全部 Mib1/Mindbomb 一抗 -
描述
兔多克隆抗体to Mib1/Mindbomb -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Drosophila melanogaster -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab74134于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 130 kDa.
|
| 说明 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 130 kDa. |
靶标
-
功能
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. -
组织特异性
Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Contains 9 ANK repeats.
Contains 2 MIB/HERC2 domains.
Contains 3 RING-type zinc fingers.
Contains 1 ZZ-type zinc finger. -
翻译后修饰
Ubiquitinated. Possibly via autoubiquitination. -
细胞定位
Cytoplasm. Cell membrane. Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. - Information by UniProt
-
别名
- DAPK-interacting protein 1 antibody
- Dip 1 antibody
- DIP-1 antibody
see all
图片
-
Western blot - Anti-Mib1/Mindbomb antibody (ab74134)Anti-Mib1/Mindbomb antibody (ab74134) + S2 cells
Predicted band size: 130 kDa
Observed band size: 130 kDa
数据表及文件
-
Datasheet download
文献 (0)
ab74134 尚未被引用在任何文献中。
