Anti-MHC Class II抗体[M5/114]
Anti-MHC Class II antibody [M5/114]
3
(3 Reviews)
|
(16 Publications)
- Flow Cyt
Supplier Data
Flow Cytometry - Anti-MHC Class II antibody [M5/114] (AB139365)
Flow cytometry analysis (surface staining) of MHCII on murine splenocytes with ab139365.
不同偶联物与剂型 (1)
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519 FITC
FITC Anti-MHC Class II antibody [M5/114]
反应性数据
产品详情
Anti-MHC Class II antibody [M5/114] (ab139365) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Functional Studies, Blocking in Mouse samples.
性能和储存信息
形式
纯化工艺
纯化说明
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MHC Class II molecules facilitate the immune system's recognition and response to pathogens by presenting processed antigenic peptides to CD4+ T lymphocytes. This activity involves their assembly within the endosomal-lysosomal system where they bind peptides derived from endocytosed proteins. MHC II is part of the major histocompatibility complex which includes other related molecules such as MHC Class I (HLA class I). The binding and presentation of peptides are central for the coordination of adaptive immune responses enhancing pathogen clearance and maintaining immunological memory.
Pathways
MHC Class II operates within the antigen processing and presentation pathway important for adaptive immunity. Its interaction with CD4+ T cells stimulates downstream signaling pathways leading to T cell activation and differentiation. Related proteins in the antigen presentation pathway include invariant chain (Ii) which guides MHC II to the endosome and HLA-DM which facilitates peptide loading. Together these proteins and pathways work to ensure effective immune surveillance and response.
产品实验方案
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文献 (16)
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Neoplasia (New York, N.Y.) 69:101222 PubMed40882404
2025
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Acta pharmaceutica Sinica. B 15:1626-1642 PubMed40370566
2025
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Cell & bioscience 15:24 PubMed39972392
2025
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Acta pharmaceutica Sinica. B 14:5479-5492 PubMed39807328
2025
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Cancer communications (London, England) 45:218-244 PubMed39698847
2024
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International journal of biological sciences 20:6073-6089 PubMed39664578
2024
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Nature immunology 25:2068-2084 PubMed39354200
2024
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Open medicine (Warsaw, Poland) 19:20240955 PubMed38799252
2024
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Journal of neuroinflammation 19:267 PubMed36333761
2022
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Comparative medicine 70:216-232 PubMed32349859
2020
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