AB50937

Anti-MGA抗体[MGA6A4H5]

Name: MGA抗体[MGA6A4H5] (ab50937)| Abcam中文官网
Brand: Abcam Limited
SKU: AB50937
Price: 4606 CNY
Availability: InStock

Anti-MGA antibody [MGA6A4H5]

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(1 Publication)

Mouse Monoclonal MGA antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MGA.

查看别名

KIAA0518, MAD5, MGA, MAX gene-associated protein, MAX dimerization protein 5

1 Images

Unknown

Western blot - Anti-MGA antibody [MGA6A4H5] (AB50937)

This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

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Molecular weight markers

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Western blot - Anti-MGA antibody [MGA6A4H5] (ab50937)

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immunising peptide

Predicted band size: 332 kDa

Observed band size: 35 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MGA6A4H5

亚型

IgG1

不含载体蛋白

应用

applications

免疫原

Recombinant Fragment Protein within Human MGA. The exact immunogen used to generate this antibody is proprietary information.

Q8IWI9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

纯化说明

Protein G purified from culture of supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum. Filtered through a 0.22µm membrane.

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The MGA protein also known as MAX gene-associated protein plays a role in gene regulation by acting as a transcriptional repressor. It has an approximate mass of 256 kDa and primarily locates itself within the nucleus. MGA exhibits a broad expression pattern found in tissues such as the brain liver and heart. The protein's structure includes several domains that allow it to interact with other proteins and DNA to modulate gene expression.

Biological function summary

MGA influences the regulation of developmental processes and cellular growth. It forms part of a complex with the MAX protein essential for its function in repressing specific gene sets. This ability allows MGA to modulate cellular differentiation and development processes. By controlling these gene sets it ensures proper cellular function and maintains homeostasis within the organism.

Pathways

MGA integrates itself into the MYC-MAX-MAD network a critical regulatory system for cell proliferation. It offers a balancing effect by counteracting the actions of MYC a protein known for promoting cell cycle progression and proliferation. MGA influences the transcription machinery through this pathway to ensure controlled cell growth. Additionally MGA-related pathways intersect with those involving the E2F family further influencing cellular proliferation and apoptosis.

MGA has significant connections to cancer particularly due to its role in the MYC-MAX-MAD pathway. Dysregulation of MGA can lead to unchecked cell growth contributing to tumor development. In particular defects in MGA have been observed in lung and other carcinomas. Its relationship with MYC protein highlights its importance as MYC overexpression often couples with reduced MGA function in these cancers. Besides cancer MGA also associates with certain neurodevelopmental disorders where its role in developmental processes becomes compromised disrupting normal neurological development.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

See full target information MGA

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 29:1800-1811.e6 PubMed31722198

2019

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2.

Applications

Unspecified application

Species

Unspecified reactive species

William Garland,Itys Comet,Mengjun Wu,Aliaksandra Radzisheuskaya,Leonor Rib,Kristoffer Vitting-Seerup,Marta Lloret-Llinares,Albin Sandelin,Kristian Helin,Torben Heick Jensen

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