AB316949

Anti-MFSD2A/NLS1抗体

Name: MFSD2A/NLS1抗体 (ab316949)| Abcam中文官网
Brand: Abcam Limited
SKU: AB316949
Price: 4900 CNY
Availability: InStock

Anti-MFSD2A/NLS1 Antibody

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Rabbit Polyclonal MFSD2A/NLS1 antibody. Suitable for WB, IHC-P and reacts with Human samples.

查看别名

MFSD2, NLS1, HMFN0656, PP9177, UNQ300/PRO341, MFSD2A, Sodium-dependent lysophosphatidylcholine symporter 1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, HsMFSD2A, MFSD2a

1 Images

Supplier Data

Western blot - Anti-MFSD2A/NLS1 Antibody (AB316949)

Gel : 8%SDS-PAGE

All lanes:

Western blot - Anti-MFSD2A/NLS1 Antibody (ab316949) at 1/500 dilution

All lanes:

human placenta tissue lysate at 40 µg

Secondary

All lanes:

HRP-conjugated Goat anti rabbit IgG at 1/500 dilution

Predicted band size: 60 kDa

false

Exposure time: 1min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MFSD2A also known as Major Facilitator Superfamily Domain-Containing Protein 2A functions as a transporter protein. It efficiently facilitates transport of specific lipids across cellular membranes. This protein has a mass of approximately 56 kDa and is mainly expressed in the blood-brain barrier and endothelial cells. MFSD2A's expression in these areas plays an important role in transport through the protective barrier in the brain.

Biological function summary

MFSD2A is important in mediating uptake of omega-3 fatty acids such as docosahexaenoic acid (DHA) into the brain. It achieves this by ensuring proper distribution of lipids necessary for maintaining brain health and function. While not known to be a part of a larger complex MFSD2A works closely with lipid molecules and other membrane transporters to regulate lipid homeostasis within the brain.

Pathways

MFSD2A is involved in the lipid metabolic pathway and the neurovascular signaling pathway. Its activity significantly affects how lipids are transported and utilized within these systems. It interacts functionally with proteins like ABC transporters which also contribute to lipid processing and transport. These pathways highlight the importance of MFSD2A in lipid utilization and brain metabolism.

MFSD2A is closely linked to neurological conditions such as microcephaly and certain neurodevelopmental disorders. Its malfunction or altered expression can disrupt the supply of essential lipids to the brain leading to developmental abnormalities. The protein's role connects to other transporters like FABP5 hinting at a network of lipid transport mechanisms that when altered contribute to these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed : 24828040, PubMed : 32572202, PubMed : 34135507). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed : 26005868, PubMed : 34135507). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed : 21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed : 18988732, PubMed : 23177091).

See full target information MFSD2A

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Anti-MFSD2A/NLS1抗体

Anti-MFSD2A/NLS1 Antibody

Western blot - Anti-MFSD2A/NLS1 Antibody (AB316949)