AB79041

Anti-MEX3C抗体

Anti-MEX3C antibody

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(1 Publication)

Rabbit Polyclonal MEX3C antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MEX3C.

查看别名

RKHD2, RNF194, BM-013, MEX3C, RNA-binding E3 ubiquitin-protein ligase MEX3C, RING finger and KH domain-containing protein 2, RING finger protein 194, RING-type E3 ubiquitin transferase MEX3C

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Western blot - Anti-MEX3C antibody (AB79041)

Lane 1:

Western blot - Anti-MEX3C antibody (ab79041) at 0.5 µg/mL

Lane 2:

Western blot - Anti-MEX3C antibody (ab79041) at 1 µg/mL

All lanes:

Rat heart tissue lysate at 15 µg

Predicted band size: 69 kDa

Observed band size: 69 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Synthetic Peptide within Human MEX3C. The exact immunogen used to generate this antibody is proprietary information.

Q5U5Q3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab79041 was purified by affinity chromatography via a peptide column

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The biological target MEX3C also known as RKHD3 or MEX-3 homolog C is a protein that functions mechanically as an RNA-binding protein. It has a mass of approximately 73 kilodaltons. MEX3C is expressed in various tissues including the brain skeletal muscle and kidney. It contains KH domains responsible for binding RNA enabling it to regulate the fate of specific mRNA molecules influencing mRNA stability and translation.

Biological function summary

MEX3C acts as a post-transcriptional regulator and is involved in mRNA decay and modulation. It does not appear to be a part of any large protein complexes but regulates the expression of a variety of cellular factors by binding target mRNAs. This control mechanism allows MEX3C to influence cell differentiation and development by affecting protein synthesis at the post-transcriptional level.

Pathways

MEX3C is implicated in the regulation of the Wnt signaling pathway and the mRNA surveillance pathway. It interacts with proteins involved in these pathways to modulate transcriptional outputs and cell signaling processes which are vital for normal embryonic development and cellular homeostasis. Proteins such as β-catenin and UPF1 may interact with MEX3C as part of these pathways aligning MEX3C actions with control of cell proliferation and gene expression.

MEX3C has connections to cancer particularly in pathways that influence tumor growth and progression. Additionally MEX3C may play a role in neurodegenerative diseases as it is involved in mRNA regulation within neurons. Disorders linked with MEX3C involve proteins like p53 which is associated with the regulation of cell cycle and apoptosis illustrating the potential impact of MEX3C on cellular outcomes that pertain to these diseases.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

See full target information MEX3C

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 12:3285-3294 PubMed31118679

2019

MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Haichao Chao,Leihong Deng,Fanghua Xu,Zhaojun Yu,Xiangda Xu,Jianbiao Huang,Tao Zeng

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Anti-MEX3C抗体

Anti-MEX3C antibody

Western blot - Anti-MEX3C antibody (AB79041)