AB109420

重组Anti-MEF2A抗体[EPR1451]

Anti-MEF2A antibody [EPR1451]

RabMAb
Recombinant
了解详情

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(9 Publications)

Rabbit Recombinant Monoclonal MEF2A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 9 publications.

查看别名

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

ab109420, at 1/100 dilution, staining MEF2A in HeLa cells by Immunohistochemistry.

Unknown

Western blot - Anti-MEF2A antibody [EPR1451] (AB109420)

All lanes:

Western blot - Anti-MEF2A antibody [EPR1451] (ab109420) at 1/10000 dilution

Lane 1:

Human heart lysate at 10 µg

Lane 2:

Human skeletal muscle lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Lane 4:

Saos-2 cell lysate at 10 µg

Predicted band size: 55 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-MEF2A antibody [EPR1451] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR1451

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.

Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

See full target information MEF2A

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed39857778

2025

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Charmy Twala,Sibusiso Malindisa,Chamone Munnik,Selisha Sooklal,Monde Ntwasa

Frontiers in bioengineering and biotechnology 10:1022830 PubMed36304901

2022

Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwen Wu,Jinghong Yuan,Jiantian Li,Zhi Du,Ming Yin,Xigao Cheng,Xijuan Liu,Jingyu Jia

Frontiers in cell and developmental biology 9:671857 PubMed34490239

2021

Lnc-GD2H Promotes Proliferation by Forming a Feedback Loop With c-Myc and Enhances Differentiation Through Interacting With NACA to Upregulate Myog in C2C12 Myoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Chen,Si Lei,Yanling She,Shanyao Zhou,Huacai Shi,Cheng Li,Ting Jiang

Frontiers in physiology 12:659272 PubMed34305633

2021

Knockdown of CNN3 Impairs Myoblast Proliferation, Differentiation, and Protein Synthesis via the mTOR Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yanling She,Cheng Li,Ting Jiang,Si Lei,Shanyao Zhou,Huacai Shi,Rui Chen

Nature communications 10:3276 PubMed31332177

2019

Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart.

Applications

Unspecified application

Species

Unspecified reactive species

Sophie Payne,Mala Gunadasa-Rohling,Alice Neal,Andia N Redpath,Jyoti Patel,Kira M Chouliaras,Indrika Ratnayaka,Nicola Smart,Sarah De Val

The Journal of neuroscience : the official journal 39:5064-5079 PubMed31015341

2019

Antagonizing Increased Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.

Applications

Unspecified application

Species

Unspecified reactive species

Vamshidhar R Vangoor,Cristina R Reschke,Ketharini Senthilkumar,Lieke L van de Haar,Marina de Wit,Giuliano Giuliani,Mark H Broekhoven,Gareth Morris,Tobias Engel,Gary P Brennan,Ronan M Conroy,Peter C van Rijen,Peter H Gosselaar,Stephanie Schorge,Roel Q J Schaapveld,David C Henshall,Pierre N E De Graan,R Jeroen Pasterkamp

Biochemical and biophysical research communication 500:645-649 PubMed29678571

2018

The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Bangfu Zhu,Ruth E Carmichael,Luis Solabre Valois,Kevin A Wilkinson,Jeremy M Henley

Scientific reports 8:5263 PubMed29588465

2018

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Applications

Unspecified application

Species

Unspecified reactive species

Ruth E Carmichael,Kevin A Wilkinson,Tim J Craig,Michael C Ashby,Jeremy M Henley

Genes & development 30:2297-2309 PubMed27898394

2016

MEF2 transcription factors are key regulators of sprouting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Sacilotto,Kira M Chouliaras,Leonid L Nikitenko,Yao Wei Lu,Martin Fritzsche,Marsha D Wallace,Svanhild Nornes,Fernando García-Moreno,Sophie Payne,Esther Bridges,Ke Liu,Daniel Biggs,Indrika Ratnayaka,Shane P Herbert,Zoltán Molnár,Adrian L Harris,Benjamin Davies,Gareth L Bond,George Bou-Gharios,John J Schwarz,Sarah De Val

View all publications

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Abcam Product Promise

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重组Anti-MEF2A抗体[EPR1451]