JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB264329

Anti-MEF2A抗体

Anti-MEF2A antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal MEF2A antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MEF2A aa 150-250.

查看别名

MEF2, MEF2A, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A antibody (AB264329)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A antibody (AB264329)

Formalin-fixed, paraffin-embedded human colon carcinoma tissue stained for MEF2A using ab264329 at 1/1000 dilution in immunohistochemical analysis. DAB staining.

Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A antibody (AB264329)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A antibody (AB264329)

Formalin-fixed, paraffin-embedded mouse renal cell carcinoma tissue stained for MEF2A using ab264329 at 1/1000 dilution in immunohistochemical analysis. DAB staining.

Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Western blot - Anti-MEF2A antibody (AB264329)
  • WB

Supplier Data

Western blot - Anti-MEF2A antibody (AB264329)

All lanes:

Western blot - Anti-MEF2A antibody (ab264329) at 0.1 µg/mL

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen)whole cell lysate at 50 µg

Lane 2:

HEK-293T whole cell lysate at 15 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 4:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Predicted band size: 55 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human MEF2A aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q02078

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": "<p>Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.</p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": "<p>Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.</p>" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MEF2A or Myocyte Enhancer Factor 2A is a transcription factor involved in regulating gene expression. MEF2A is approximately 55 kDa in size and is expressed in a variety of tissues including muscle brain and heart. It is part of the MEF2 family of transcription factors which all share a similar MADS-box/MEF2 domain structure. MEF2A binds to DNA and influences the transcription of genes involved in muscle differentiation and development.
Biological function summary

MEF2A participates in transcriptional regulation as part of a larger complex that includes other regulatory proteins. This transcription factor plays an essential role in the development and function of muscles. It activates the transcription of genes necessary for muscle fiber formation and adaptation. MEF2A also influences the expression of genes related to neuronal survival and plasticity impacting cognitive function and memory in the brain.

Pathways

MEF2A is involved in both the MAPK/ERK and PI3K/Akt pathways which are significant for cellular growth survival and differentiation. MEF2A interacts with proteins like MAPK and PI3K impacting these signaling pathways that regulate cell proliferation and apoptosis. This interaction highlights its role in cellular response to external stimuli and stress signals positioning MEF2A as an important factor in cell fate decisions.

Mutations or dysregulation of MEF2A are connected to cardiovascular diseases particularly coronary artery disease. MEF2A mutations can disrupt normal transcriptional regulation leading to impaired cardiovascular function. Additionally alterations in MEF2A function are linked to neurodegenerative disorders such as Alzheimer's disease where it may interact with proteins including Tau and amyloid precursor protein influencing neuronal health and survival.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
See full target information MEF2A
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cellular & molecular biology letters 29:154 PubMed39695937

2024

Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Zhang,Wenyu Zou,Shixuan Zhang,Honghua Wu,Ying Gao,Junqing Zhang,Jia Zheng

Autophagy 20:505-524 PubMed37772772

2023

Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Li Xia,Tiejian Nie,Fangfang Lu,Lu Huang,Xiaolong Shi,Dongni Ren,Jianjun Lu,Xiaobin Li,Tuo Xu,Bozhou Cui,Qing Wang,Guodong Gao,Qian Yang
View all publications
style
left-column
style
left-column
style
right-column

替代产品

Primary Antibodies

AB30644

Anti-MEF2A (phospho T312) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEF2A (phospho T312) antibody (AB30644)

  • 4
  • 2
Primary Antibodies

AB76063

Anti-MEF2A antibody [EP1706Y]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-MEF2A antibody [EP1706Y] (AB76063)

  • 5
  • 2
Primary Antibodies

AB109420

Anti-MEF2A antibody [EPR1451]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] (AB109420)

  • 0
  • 0
Primary Antibodies

AB235999

Anti-MEF2A antibody [EP1706Y] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-MEF2A antibody [EP1706Y] - BSA and Azide free (AB235999)

  • 0
  • 0
Primary Antibodies

AB247854

Anti-MEF2A antibody [EPR1451] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-MEF2A antibody [EPR1451] - BSA and Azide free (AB247854)

  • 0
  • 0
Primary Antibodies

AB181494

Anti-MEF2A antibody [2F9H2]

Western blot - Anti-MEF2A antibody [2F9H2] (AB181494)

  • 0
  • 0

搭配使用产品

Assay Kits

AB314602

Human MEF2A ELISA Kit

SimpleStep

Sandwich ELISA - Human MEF2A ELISA Kit (AB314602)

  • 0
  • 0
Primary Antibodies

AB92443

Anti-Menin antibody [EPR3986]

Advanced Validation|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Menin antibody [EPR3986] (AB92443)

  • 0
  • 0
Primary Antibodies

AB315332

Anti-CPEB4 antibody [EPR27416-141]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CPEB4 antibody [EPR27416-141] (AB315332)

  • 0
  • 0
Primary Antibodies

AB302646

Anti-Cathepsin D antibody [EPR3057Y] - Chicken IgY (Chimeric)

BOND RX™ Validated|20ul selling size|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-Cathepsin D antibody [EPR3057Y] - Chicken IgY (Chimeric) (AB302646)

  • 0
  • 0
Primary Antibodies

AB63856

Anti-Osteopontin antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Osteopontin antibody (AB63856)

  • 0
  • 1

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com