JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121519

Anti-MCT 10抗体

Anti-MCT 10 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal MCT 10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus.

查看别名

MCT10, TAT1, SLC16A10, Monocarboxylate transporter 10, MCT 10, Aromatic amino acid transporter 1, Solute carrier family 16 member 10, T-type amino acid transporter 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-MCT 10 antibody (AB121519)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-MCT 10 antibody (AB121519)

Immunofluorescent staining of MCT 10 using ab121519 at 2 μg/ml in human cell line CACO-2

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 10 antibody (AB121519)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MCT 10 antibody (AB121519)

ab121519 at 1/10 dilution staining MCT 10 in Paraffin-embedded Human Skeletal muscle tissue by Immunohistochemistry.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human SLC16A10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TF71

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.2-0.25 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MCT 10 also known as SLC16A10 is a member of the monocarboxylate transporter family. This transporter protein has a mass of approximately 58 kDa and facilitates the transport of aromatic amino acids across cell membranes. MCT 10 is mainly expressed in tissues like the small intestine liver kidney and placenta. It functions as a sodium-independent transporter which distinguishes it from other amino acid transporters that may rely on sodium gradients.
Biological function summary

MCT 10 plays a significant role in the cellular uptake and export of aromatic amino acids like tryptophan phenylalanine and tyrosine. These amino acids are essential precursors for the synthesis of important biological compounds. MCT 10 is not part of a larger protein complex but operates individually to facilitate these transport processes. Its function provides cells with necessary aromatic amino acids for various metabolic pathways and supports the body's metabolic needs.

Pathways

MCT 10 is a critical component in amino acid transport and metabolism. It is closely linked with pathways involving protein synthesis and neurotransmitter production. The transport activity of MCT 10 influences the concentration of precursor molecules for synthesis of proteins and neurotransmitters. MCT 10 works alongside other transporter proteins such as LAT1 within these metabolic pathways to ensure efficient cellular function and communication.

Impaired function of MCT 10 has been associated with certain inherited disorders of amino acid metabolism. These disorders can alter the normal balance of amino acids leading to metabolic complications. Aberrations in MCT 10 expression or function may also have implications in metabolic diseases and could affect related proteins like LAT1 which share similar transport duties and substrate specificities. Research on MCT 10 may unveil new insights into therapeutic targets for addressing disorders of amino acid metabolism.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed : 11827462, PubMed : 18337592, PubMed : 28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed : 18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed : 11827462, PubMed : 28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity).
See full target information SLC16A10
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research 38:25 PubMed30658672

2019

DHHC protein family targets different subsets of glioma stem cells in specific niches.

Applications

Unspecified application

Species

Unspecified reactive species

Xueran Chen,Lei Hu,Haoran Yang,Huihui Ma,Kaiqin Ye,Chenggang Zhao,Zhiyang Zhao,Haiming Dai,Hongzhi Wang,Zhiyou Fang

Frontiers in neuroscience 9:123 PubMed25972776

2015

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study.

Applications

Unspecified application

Species

Unspecified reactive species

Norman R Saunders,Katarzyna M Dziegielewska,Kjeld Møllgård,Mark D Habgood,Matthew J Wakefield,Helen Lindsay,Nathalie Stratzielle,Jean-Francois Ghersi-Egea,Shane A Liddelow
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0
Primary Antibodies

AB118800

Anti-ZZZ3 antibody

Western blot - Anti-ZZZ3 antibody (AB118800)

  • 0
  • 0
Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

BOND RX™ Validated

Western blot - Anti-alpha Tubulin antibody [DM1A] - Loading Control (AB7291)

  • 5
  • 92

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com