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AB244927

重组Anti-MCP2抗体[EPR20081-86] - BSA and Azide free (Detector)

Anti-MCP2 antibody [EPR20081-86] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal MCP2 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

查看别名

MCP2, SCYA10, SCYA8, CCL8, C-C motif chemokine 8, HC14, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, Small-inducible cytokine A8, MCP-2

1 Images
Sandwich ELISA - Anti-MCP2 antibody [EPR20081-86] - BSA and Azide free (Detector) (AB244927)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-MCP2 antibody [EPR20081-86] - BSA and Azide free (Detector) (AB244927)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab223856).

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR20081-86

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

sELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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搭配使用产品

Assay Kits

AB223856

Human MCP2 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human MCP2 ELISA Kit (AB223856)

  • 0
  • 0
Sample Prep & Detection Kits

AB102850

Alkaline phosphatase Conjugation Kit - Lightning-Link®

Conjugation - Alkaline phosphatase Conjugation Kit - Lightning-Link® (AB102850)

  • 4
  • 1
Sample Prep & Detection Kits

AB269889

Europium Conjugation Kit

Dot Blot - Europium Conjugation Kit (AB269889)

  • 0
  • 0
Primary Antibodies

AB242545

Anti-MIP-1 alpha/CCL3 + CCL4/MIP-1 beta antibody [EPR19900-275] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-MIP-1 alpha/CCL3 + CCL4/MIP-1 beta antibody [EPR19900-275] - BSA and Azide free (Capture) (AB242545)

  • 0
  • 0
Primary Antibodies

AB242969

Anti-CXCL9 antibody [EPR18732-17] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-CXCL9 antibody [EPR18732-17] - BSA and Azide free (Capture) (AB242969)

  • 0
  • 0
Primary Antibodies

AB259747

Anti-MMP12 antibody [EPR22228-101] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-MMP12 antibody [EPR22228-101] - BSA and Azide free (Capture) (AB259747)

  • 0
  • 0
Primary Antibodies

AB308079

Anti-G-CSF antibody [EPR22390-163] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-G-CSF antibody [EPR22390-163] - BSA and Azide free (Capture) (AB308079)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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产品详情

ab244927 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human MCP2. The recommended pair for sandwich ELISA is:
Capture: ab244845, Human MCP2 Capture Antibody (unconjugated)
Detector: ab244927, Human MCP2 Detector Antibody (unconjugated)
The reference range value is 1.25 - 160 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MCP2 also known as CCL8 or monocyte chemoattractant protein-2 plays an important role in leukocyte trafficking. This chemokine has a molecular weight of approximately 8 kDa. CCL8 is expressed in various tissues including macrophages fibroblasts and endothelial cells and it is particularly high during inflammatory responses. The MCP2 protein attracts immune cells such as monocytes and T cells to sites of infection or injury.
Biological function summary

MCP2 influences the migration and activation of leukocytes enhancing the body's immune response. MCP2 interacts with chemokine receptors like CCR2 and CCR5 facilitating the movement of immune cells through tissues. This protein is not usually part of larger complexes but works closely with other chemokines to coordinate cellular responses during inflammation. MCP2 activity is important in processes that require rapid cell recruitment and immune surveillance.

Pathways

MCP2 functions within the chemokine signaling pathway and plays a significant part in the inflammatory response pathway. MCP2 closely interacts with chemokine receptors such as CCR2 which is also engaged by related chemokines like MCP1 (CCL2). MCP2 and MCP1 share functional similarities in modulating the immune response though they target different receptor profiles that expand their influence across numerous immune processes.

MCP2 is associated with inflammatory diseases and certain types of cancer. Rheumatoid arthritis shows heightened levels of MCP2 contributing to the persistent inflammation characteristic of the disorder. Elevated MCP2 levels have also been noticed in tumor microenvironments suggesting a role in cancer metastasis where it might interact with proteins such as IL-6 to promote the survival and migration of tumor cells.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
See full target information CCL8
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