Anti-MC1-R抗体(ab180776)
Key features and details
- Rabbit polyclonal to MC1-R
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
概述
-
产品名称
Anti-MC1-R抗体
参阅全部 MC1-R 一抗 -
描述
兔多克隆抗体to MC1-R -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Synthetic peptide within Human MC1-R. The exact sequence is proprietary.
Database link: Q01726 -
阳性对照
- Mouse intestinum tenue tissue lysate.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab180776于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 35 kDa.
|
| 说明 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 35 kDa. |
靶标
-
功能
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
组织特异性
Melanocytes and corticoadrenal tissue. -
疾病相关
Genetic variations in MC1R are a cause of susceptibility to cutaneous malignant melanoma type 5 (CMM5) [MIM:613099]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 17199 Mouse
- SwissProt: Q01727 Mouse
- Unigene: 324942 Mouse
-
别名
- CMM5 antibody
- MC1 Receptor antibody
- MC1-R antibody
see all
图片
-
Western blot - Anti-MC1-R antibody (ab180776)Anti-MC1-R antibody (ab180776) at 1/500 dilution + Mouse intestinum tenue tissue lysate
Predicted band size: 35 kDa
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab180776 被引用在 5 文献中.
- Lan J et al. Functional characterization of cAMP signaling of variant porcine MC1R alleles in PK15 cells. Anim Genet 53:317-326 (2022). PubMed: 35292981
- Fan K et al. Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect. Theranostics 11:2670-2690 (2021). PubMed: 33456566
- Maisto R et al. ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5. Cell Cycle 18:413-424 (2019). PubMed: 30739530
- Wu X et al. NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-?B pathway after intracerebral hemorrhage in mice. J Neuroinflammation 16:192 (2019). PubMed: 31660977
- Li YX et al. Construction of MC1R and ASIP Eukaryotic Expression Vector and its Regulation of Plumage Color in Japanese Quail (Coturnix japonica). J Poult Sci 56:84-90 (2019). PubMed: 32055201