AB56180

Anti-Matriptase 2抗体-细胞质domain

Name: Matriptase 2抗体- Cytoplasmic domain (ab56180)| Abcam中文官网
Brand: Abcam Limited
SKU: AB56180
Price: 4977 CNY
Availability: InStock
Rating: 5 (2 reviews)

Anti-Matriptase 2 antibody - Cytoplasmic domain

(2 Reviews)

(6 Publications)

Rabbit Polyclonal Matriptase 2 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TMPRSS6.

查看别名

UNQ354/PRO618, TMPRSS6, Transmembrane protease serine 6, Matriptase-2

1 Images

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Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (AB56180)

All lanes:

Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (ab56180) at 1/1000 dilution

All lanes:

Cell media from human embryonic kidney HEK293 cells

Predicted band size: 90 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human TMPRSS6. The exact immunogen used to generate this antibody is proprietary information.

Q8IU80

特异性

ab56180 reacts with Matripase 2 (TMPRSS6) and does not react with the other TMPRSSs. ab56180 recognizes all of the listed forms of Matripase 2.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Membrane-bound serine protease (PubMed : 18976966, PubMed : 20518742, PubMed : 25156943, PubMed : 25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed : 18408718, PubMed : 18976966, PubMed : 25156943).

See full target information TMPRSS6

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35163229

2022

SEC23B Loss-of-Function Suppresses Hepcidin Expression by Impairing Glycosylation Pathway in Human Hepatic Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara Eleni Rosato,Roberta Marra,Vanessa D'Onofrio,Federica Del Giudice,Simone Della Monica,Achille Iolascon,Immacolata Andolfo,Roberta Russo

Cells 10: PubMed34571900

2021

HCV-Induced Immunometabolic Crosstalk in a Triple-Cell Co-Culture Model Capable of Simulating Systemic Iron Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Pelagia Foka,Alexios Dimitriadis,Eirini Karamichali,Emmanouil Kochlios,Petros Eliadis,Vaia Valiakou,John Koskinas,Avgi Mamalaki,Urania Georgopoulou

FEBS open bio 11:237-250 PubMed33247551

2020

The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Alexios Dimitriadis,Pelagia Foka,Eleni Kyratzopoulou,Eirini Karamichali,Stavroula Petroulia,Panagiota Tsitoura,Athanasios Kakkanas,Petros Eliadis,Urania Georgopoulou,Avgi Mamalaki

The Journal of biological chemistry 291:20387-401 PubMed27502273

2016

The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage.

Applications

Unspecified application

Species

Unspecified reactive species

Shawn M Lamothe,Jun Guo,Wentao Li,Tonghua Yang,Shetuan Zhang

Cellular and molecular life sciences : CMLS 71:4243-58 PubMed24718935

2014

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Applications

Species

Unspecified reactive species

Pelagia Foka,Alexios Dimitriadis,Eleni Kyratzopoulou,Dionysios A Giannimaras,Stefania Sarno,George Simos,Urania Georgopoulou,Avgi Mamalaki

The Journal of biological chemistry 286:4090-7 PubMed20966077

2010

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Applications

Species

Human

Samira Lakhal,Johannes Schödel,Alain R M Townsend,Christopher W Pugh,Peter J Ratcliffe,David R Mole

View all publications

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Anti-Matriptase 2抗体-细胞质domain

Anti-Matriptase 2 antibody - Cytoplasmic domain

Western blot - Anti-Matriptase 2 antibody - Cytoplasmic domain (AB56180)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性