AB106388

Anti-MATN3/Matrilin-3抗体

Name: MATN3/Matrilin-3抗体 (ab106388)| Abcam中文官网
Brand: Abcam Limited
SKU: AB106388
Price: 4606 CNY
Availability: InStock

Anti-MATN3/Matrilin-3 antibody

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(3 Publications)

Rabbit Polyclonal MATN3/Matrilin-3 antibody. Suitable for WB and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human MATN3.

查看别名

Matrilin-3, MATN3

1 Images

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Western blot - Anti-MATN3/Matrilin-3 antibody (AB106388)

Lane 1:

Western blot - Anti-MATN3/Matrilin-3 antibody (ab106388) at 1 µg/mL

Lane 2:

Western blot - Anti-MATN3/Matrilin-3 antibody (ab106388) at 2 µg/mL

All lanes:

Rat thymus tissue lysate at 15 µg

Predicted band size: 52 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Synthetic Peptide within Human MATN3. The exact immunogen used to generate this antibody is proprietary information.

O15232

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Matrilin-3 also known as MATN3 is a disease-associated protein involved in cartilage extracellular matrix organization. Matrilin-3 is a member of the matrilin protein family which includes other family members like matrilin-1 and matrilin-4. The protein has a molecular mass of approximately 54 kDa. It is expressed mainly in cartilage tissue with significant presence in the growth plate cartilage which is important during development.

Biological function summary

Matrilin-3 contributes to the structural integrity of cartilage by forming filamentous networks in the extracellular matrix. It is part of a larger protein complex that includes collagen oligomeric matrix proteins and other structural components. Matrilin-3's affinity for interacting with other matrix components helps maintain cartilage homeostasis supporting overall tissue function and resilience.

Pathways

Matrilin-3 plays a role in organizing the extracellular matrix within the skeletal dysplasia pathway. This pathway includes other proteins like collagen types II and IX which work together to ensure proper cartilage framework and maintenance. Matrilin-3's involvement in these pathways highlights its role in skeletal development and the maintenance of cartilage health.

Matrilin-3 is linked to multiple epiphyseal dysplasia (MED) and osteoarthritis. Mutations in the MATN3 gene disrupt normal protein function and cartilage structure leading to MED a disorder characterized by joint pain and skeletal abnormalities. During osteoarthritis progression altered matrilin-3 expression correlates with cartilage degradation. Associated proteins like collagen type II are also implicated in these disease processes connecting matrilin-3 function with broader cartilage-related pathologies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.

See full target information MATN3

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:14654 PubMed40287463

2025

Comprehensive identification of dysregulated extracellular matrix molecules in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Soichiro Inagaki,Hanielle Vaitinadapoule,Taichi Yuasa,Tatsuya Nakagawa,Masaya Ikegawa,Yumiko Toyama,Takashi Nirasawa,Yuichi Tokuda,Masakazu Nakano,Kei Tashiro,Theofilos Tourtas,Ursula Schlötzer-Schrehardt,Friedrich Kruse,Ines Aouimeur,Zhiguo He,Philippe Gain,Noriko Koizumi,Gilles Thuret,Naoki Okumura

Cellular & molecular biology letters 23:7 PubMed29483929

2018

Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Yang,Di Wu,Hua Li,Nan Chen,Yongjun Shang

Medical science monitor : international medical jo 24:348-355 PubMed29343680

2018

Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance.

Applications

Unspecified application

Species

Unspecified reactive species

Ping-Li Wu,Yi-Fu He,Han-Hui Yao,Bing Hu

View all publications

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Anti-MATN3/Matrilin-3抗体

Anti-MATN3/Matrilin-3 antibody

Western blot - Anti-MATN3/Matrilin-3 antibody (AB106388)