Anti-MAT1A抗体(ab174687)
Key features and details
- Rabbit polyclonal to MAT1A
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MAT1A抗体
参阅全部 MAT1A 一抗 -
描述
兔多克隆抗体to MAT1A -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human MAT1A aa 114-144 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
Sequence:SPDIAQCVHLDRNEEDV GAGDQGLMFG YATD
Database link: Q00266 -
阳性对照
- MDA-MB435 cell line lysates; Human lung tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab174687于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 5 µg/ml.
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| WB |
1/100 - 1/500. Predicted molecular weight: 43 kDa.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 5 µg/ml. |
|
WB
1/100 - 1/500. Predicted molecular weight: 43 kDa. |
靶标
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相关性
MAT1A catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. Mutations in this gene are associated with methionine adenosyltransferase deficiency. -
数据库链接
- Entrez Gene: 4143 Human
- Omim: 610550 Human
- SwissProt: Q00266 Human
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别名
- AdoMet antibody
- AdoMet synthetase 1 antibody
- AI046368 antibody
see all
图片
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Western blot - Anti-MAT1A antibody (ab174687)Anti-MAT1A antibody (ab174687) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg
Predicted band size: 43 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAT1A antibody (ab174687)Immunohistochemical analysis of paraffin embedded formalin fixed Human lung tissue labeling MAT1A using ab174687 at 5 µg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab174687 被引用在 3 文献中.
- Wang K et al. TGF-ß1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM. EBioMedicine 42:458-469 (2019). PubMed: 30926424
- Martin KA et al. Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. Int J Mol Sci 20:N/A (2019). PubMed: 31600961
- Wang J et al. MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression. Life Sci 234:116771 (2019). PubMed: 31421084