AB91640

Anti-MARVELD1抗体

Name: MARVELD1抗体 (ab91640)| Abcam中文官网
Brand: Abcam Limited
SKU: AB91640
Price: 4514 CNY
Availability: InStock

Anti-MARVELD1 antibody

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(7 Publications)

Rabbit Polyclonal MARVELD1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human MARVELD1.

查看别名

MRVLDC1, MARVELD1, MARVEL domain-containing protein 1

1 Images

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Western blot - Anti-MARVELD1 antibody (AB91640)

Lane 1:

Western blot - Anti-MARVELD1 antibody (ab91640) at 1 µg/mL

Lane 2:

Western blot - Anti-MARVELD1 antibody (ab91640) at 2 µg/mL

All lanes:

Mouse heart lysate at 15 µg

Predicted band size: 19 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

applications

免疫原

Synthetic Peptide within Human MARVELD1. The exact immunogen used to generate this antibody is proprietary information.

Q9BSK0

特异性

Specific for MARVELD1. Does not bind to other MARVELD proteins.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

MARVELD1 also known as MARVEL domain-containing 1 is a protein with a mass of approximately 13 kDa. It is a membrane-associated protein that contains a MARVEL domain involved in membrane apposition processes. MARVELD1 is mainly expressed in various tissues such as kidney liver and lung. Its expression is often subject to change in different cellular and physiological contexts reflecting its diverse roles in the body.

Biological function summary

The protein plays a role in cell growth regulation and cellular transport mechanisms. MARVELD1 is linked to cellular processes and is a component of membrane-associated complexes. These complexes may influence cellular communication and intracellular signaling pathways which are vital for maintaining normal cell function and growth. Understanding the behavior of MARVELD1 in various cellular compartments sheds light on its regulation in health and disease.

Pathways

MARVELD1 participates in pathways associated with cell proliferation and apoptosis. It interacts with proteins involved in the PI3K/AKT signaling pathway which affects cell survival and growth. Also MARVELD1 shows interaction with the TGF-beta signaling pathway. These interactions play an important role in regulating cellular homeostasis and can influence cellular responses to external stimuli contributing to cellular stability or transformation.

Researchers have found that MARVELD1 has connections to cancer progression. Abnormal expression of MARVELD1 has been observed in various cancers including breast and ovarian cancer. The protein might interact with well-known cancer-related proteins such as p53 which plays a role in preventing tumor development. By understanding these interactions scientists gain insight into the mechanisms of oncogenesis and tumor progression making MARVELD1 a significant focus for cancer research.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.

See full target information MARVELD1

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Annals of translational medicine 7:200 PubMed31205918

2019

MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production.

Applications

Unspecified application

Species

Unspecified reactive species

Wenping Ma,Haiyang Shen,Qian Li,Hao Song,Yanyan Guo,Fangrong Li,Xingang Zhou,Xinwu Guo,Jingdong Shi,Qi Cui,Jinhao Xing,Jinhai Deng,Youtao Yu,Wenjie Liu,Hongshan Zhao

Molecular carcinogenesis 58:1410-1426 PubMed31066116

2019

MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.

Applications

Unspecified application

Species

Unspecified reactive species

Chunbin Zhang,Fang Han,Ming Shi,Haoxiu Sun,Yiqun Li,Yanpeng Ci,Yuanfei Yao,Peng Dou,Muhammad Luqman Akhtar,Huan Nie,Jie He,Yu Li

Cell death & disease 9:999 PubMed30250269

2018

MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development.

Applications

Unspecified application

Species

Unspecified reactive species

Weizhe Liu,Fang Han,Shuai Qu,Yuanfei Yao,Jianxiang Zhao,Muhammad Luqman Akhtar,Yanpeng Ci,Hao Zhang,Hongfei Li,Yufang Zhao,Lei Yue,Yao Zhang,Changlin Wang,Yu Li

Journal of cellular physiology 233:2257-2269 PubMed28708243

2017

The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Chen,Hui Zhang,Fang Han,Lei Yue,Chunxiao Qiao,Yao Zhang,Peng Dou,Weizhe Liu,Yu Li

Respiratory research 16:147 PubMed26646719

2015

The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge.

Applications

Species

Unspecified reactive species

Joanna Wieczfinska,Dorota Kacprzak,Karolina Pospiech,Milena Sokolowska,Magdalena Nowakowska,Ewa Pniewska,Andrzej Bednarek,Izabela Kuprys-Lipinska,Piotr Kuna,Rafal Pawliczak

Molecular carcinogenesis 55:1714-1727 PubMed26509557

2015

MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanfei Yao,Ming Shi,Shanshan Liu,Yiqun Li,Kexin Guo,Yanpeng Ci,Weizhe Liu,Yu Li

PloS one 8:e68291 PubMed23826386

2013

MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.

Applications

Species

Human

Jianran Hu,Yu Li,Ping Li

View all publications

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Anti-MARVELD1抗体

Anti-MARVELD1 antibody

Western blot - Anti-MARVELD1 antibody (AB91640)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性