Anti-MARCKS抗体(ab51100)
Key features and details
- Rabbit polyclonal to MARCKS
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MARCKS抗体
参阅全部 MARCKS 一抗 -
描述
兔多克隆抗体to MARCKS -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
A synthentic non-phosphopeptide derived from human MARCKS around the phosphorylation site of serine 162 (K-K-SP-F-K).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab51100 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab51100于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. -
序列相似性
Belongs to the MARCKS family. -
翻译后修饰
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. -
细胞定位
Cytoplasm > cytoskeleton. Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 4082 Human
- Omim: 177061 Human
- SwissProt: P29966 Human
- Unigene: 519909 Human
- Unigene: 712721 Human
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别名
- 80 kDa protein antibody
- 80K L antibody
- 80K L protein antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab51100 被引用在 6 文献中.
- O'Callaghan AA et al. Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection. Front Cell Infect Microbiol 11:622491 (2021). PubMed: 34350128
- Wang Y et al. Adipokine RBP4 drives ovarian cancer cell migration. J Ovarian Res 11:29 (2018). PubMed: 29642915
- Song HM et al. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. Int J Mol Med 42:193-207 (2018). PubMed: 29620148
- Johnston DGW et al. MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. Front Cell Infect Microbiol 7:201 (2017). PubMed: 28589100
- Qi X et al. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med 213:2081-97 (2016). WB . PubMed: 27551156
- Rodriguez Peña MJ et al. MARCKS Protein Is Phosphorylated and Regulates Calcium Mobilization during Human Acrosomal Exocytosis. PLoS One 8:e64551 (2013). WB ; Human . PubMed: 23704996