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Signal Transduction Protein Phosphorylation Tyrosine Kinases Other
重组RabMAb

重组Anti-MAP3K4抗体[EP551Y] (ab40784)

  • Datasheet
  • SDS
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Western blot - Anti-MAP3K4 antibody [EP551Y] (ab40784)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAP3K4 antibody [EP551Y] (ab40784)
  • Anti-MAP3K4 antibody [EP551Y] (ab40784)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EP551Y] to MAP3K4
  • Suitable for: IHC-P, WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

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概述

  • 产品名称

    Anti-MAP3K4抗体[EP551Y]
    参阅全部 MAP3K4 一抗
  • 描述

    兔单克隆抗体[EP551Y] to MAP3K4
  • 宿主

    Rabbit
  • 特异性

    This antibody is predicted to detect splice isoform 2 based on sequence analysis.
  • 经测试应用

    适用于: IHC-P, WBmore details
    不适用于: IP
  • 种属反应性

    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human MAP3K4 aa 150-250.
    Database link: Q9Y6R4

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 40% Glycerol (glycerin, glycerine), 0.05% BSA, 59% PBS
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 克隆

    单克隆
  • 克隆编号

    EP551Y
  • 同种型

    IgG
  • 研究领域

    • Signal Transduction
    • Protein Phosphorylation
    • Tyrosine Kinases
    • Other
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • MAPK Pathway
    • Neuroscience
    • Neurology process
    • Neurogenesis

相关产品

  • Alternative Versions

    • Anti-MAP3K4 antibody [EP551Y] - BSA and Azide free (ab239829)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab40784于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
IHC-P
Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB
1/1000 - 1/5000. Detects a band of approximately 200 kDa (predicted molecular weight: 182 kDa).
说明
IHC-P
Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB
1/1000 - 1/5000. Detects a band of approximately 200 kDa (predicted molecular weight: 182 kDa).
应用说明
Is unsuitable for IP.

靶标

  • 功能

    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
  • 组织特异性

    Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
  • 序列相似性

    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 细胞定位

    Cytoplasm > perinuclear region. Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.
  • Target information above from: UniProt accession Q9Y6R4 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 4216 Human
    • Omim: 602425 Human
    • SwissProt: Q9Y6R4 Human
    • Unigene: 390428 Human
    • 别名

      • dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody
      • FLJ42439 antibody
      • KIAA0213 antibody
      • M3K4_HUMAN antibody
      • MAP three kinase 1 antibody
      • MAP/ERK kinase kinase 4 antibody
      • MAP3K4 antibody
      • MAPK/ERK kinase kinase 4 antibody
      • MAPKKK4 antibody
      • MEK kinase 4 antibody
      • MEKK 4 antibody
      • MEKK4 antibody
      • Mitogen-activated protein kinase kinase kinase 4 antibody
      • MTK1 antibody
      • predicted protein of HQ0412 antibody
      • PRO0412 antibody
      • RP3-473J16.4 antibody
      • SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of antibody
      see all

    图片

    • Western blot - Anti-MAP3K4 antibody [EP551Y] (ab40784)
      Western blot - Anti-MAP3K4 antibody [EP551Y] (ab40784)
      Anti-MAP3K4 antibody [EP551Y] (ab40784) at 1/1000 dilution + 293 cell lysate. at 10 µg

      Predicted band size: 182 kDa
      Observed band size: 200 kDa why is the actual band size different from the predicted?

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAP3K4 antibody [EP551Y] (ab40784)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAP3K4 antibody [EP551Y] (ab40784)

      Immunohistochemical analysis of paraffin-embedded human ovary adenocarcinoma using ab40784.

      Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    • Anti-MAP3K4 antibody [EP551Y] (ab40784)
      Anti-MAP3K4 antibody [EP551Y] (ab40784)

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (1)

    发表研究结果有使用 ab40784?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab40784 被引用在 1 文献中.

    • Duan JL  et al. A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma. Mol Cancer 21:93 (2022). PubMed: 35366894

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