重组Anti-MALT1/MLT抗体[EPR604] (ab109724)
![Western blot - Anti-MALT1/MLT antibody [EPR604] (ab109724)](https://www.abcam.cn/ps/products/109/ab109724/Images/ab109724-122672-anti-malt1-antibody-epr604-western-blot.jpg "Western blot - Anti-MALT1/MLT antibody [EPR604] (ab109724)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR604] to MALT1/MLT
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-MALT1/MLT抗体[EPR604]
参阅全部 MALT1/MLT 一抗 -
描述
兔单克隆抗体[EPR604] to MALT1/MLT -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,IHC-P or IP -
种属反应性
与反应: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Jurkat,K562,bone marrow, and PBMC lysates
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR604 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab109724于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 92 kDa.
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| 说明 |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 92 kDa. |
应用说明
Is unsuitable for Flow Cyt,IHC-P or IP.
靶标
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功能
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. -
组织特异性
Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. -
疾病相关
Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. -
序列相似性
Belongs to the peptidase C14B family.
Contains 1 death domain.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
细胞定位
Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. - Information by UniProt
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数据库链接
- Entrez Gene: 10892 Human
- Omim: 604860 Human
- SwissProt: Q9UDY8 Human
- Unigene: 601217 Human
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别名
- Caspase like protein antibody
- DKFZp434L132 antibody
- IMD12 antibody
see all
图片
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Western blot - Anti-MALT1/MLT antibody [EPR604] (ab109724)All lanes : Anti-MALT1/MLT antibody [EPR604] (ab109724) at 1/1000 dilution
Lane 1 : Jurkat lysate
Lane 2 : K562 lysate
Lane 3 : Bone marrow lysate
Lane 4 : PBMC lysates
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 92 kDa -
![Anti-MALT1/MLT antibody [EPR604] (ab109724)](https://www.abcam.cn/ps/products/109/ab109724/Images/ab109724-2-benefits-of-recombinant-antibodies.png)
Anti-MALT1/MLT antibody [EPR604] (ab109724)
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab109724 尚未被引用在任何文献中。