AB27642

Anti-Malondialdehyde抗体

Name: Malondialdehyde抗体 (ab27642)| Abcam中文官网
Brand: Abcam Limited
SKU: AB27642
Price: 5065 CNY
Availability: InStock
Rating: 5 (6 reviews)

Anti-Malondialdehyde antibody

(6 Reviews)

(55 Publications)

Anti-Malondialdehyde antibody (ab27642) is a rabbit polyclonal antibody detecting Malondialdehyde in Western Blot, ELISA.

- Over 30 publications
- Trusted since 2006

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1133 Tetramethoxypropane

2 Images

CiteAb

Western blot - Anti-Malondialdehyde antibody (AB27642)

Malondialdehyde western blot using Anti-Malondialdehyde antibody ab27642. Publication image and figure legend from Wang, C., Zhao, Y., et al., 2025, PLoS One, PubMed 40173155.

Oxidative stress (OS) responses in the testis tissues.A) Bands of OS-related proteins in the testis tissue. B-D) Quantification of protein expressions. SOD and Nrf2 expressions were downregulated, and MDA expression was upregulated after PM2.5 exposure, which was reversed after vitamin intervention. The assay was repeated thrice, and the data are presented as means ± standard deviation. * p < < 0.05 vs. control rats, #p < < 0.05 vs. PM2.5 rats.https : //doi.org/10.5061/dryad.8kprr4xxq.

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CiteAb

Western blot - Anti-Malondialdehyde antibody (AB27642)

Malondialdehyde western Blot using Anti-Malondialdehyde antibody ab27642. Publication image and figure legend from Huang, Y. J., Wang, P. M., et al., 2022, PLoS One PubMed 35793323.

Fetal liver oxidative stress.(a) western blotting of MDA expression and (b) antioxidative stress GPX1 expression. NCD : normal-chow diet, HFD : high-fat diet, HFSB : high-fat diet with butyrate supplementation during pregnancy (n = 6), * p < 0.05.

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

应用

WB, Conjugation, ELISA

applications

特异性

This antibody specifically binds to Malondialdehyde LDL and other Malondialdehyde modified proteins.

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反应性数据

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产品详情

Product Specifications

Anti-Malondialdehyde antibody (ab27642) is a rabbit polyclonal antibody and is validated for use in Conjugation, ELISA, WB.
Anti-Malondialdehyde antibody (ab27642) specifically detects Malondialdehyde (UniProt ID: ; Molecular weight: kDa) and is sold in 100 µg selling sizes.

Quality and Validation

Abcam's high quality validation processes ensure Anti-Malondialdehyde antibody (ab27642) has high sensitivity and specificity.
Anti-Malondialdehyde antibody (ab27642) has been cited over 34 times in peer reviewed journals and is trusted by the scientific community.
Anti-Malondialdehyde antibody (ab27642) has 6 independent reviews from customers.

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性能和储存信息

形式

Liquid

纯化说明

This antibody was purified by MDA modified protein Sepharose affinity column.

存储溶液

pH: 7.2 - 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.435% Sodium chloride, 0.0292% EDTA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle|Do Not Freeze

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Malondialdehyde often abbreviated as MDA is a reactive organic compound formed by the degradation of polyunsaturated lipids. This breakdown occurs through lipid peroxidation which results in MDA being a well-recognized marker for oxidative stress. The molecular mass of malondialdehyde is relatively low around 72.06 g/mol. This small molecule does not localize to specific tissues but instead it can be found throughout the body wherever lipid peroxidation occurs making it widespread in biological systems.

Biological function summary

This compound plays an important role in signaling processes related to oxidative stress. MDA is not part of a protein complex but it interacts with proteins by forming adducts with lysine and histidine residues. Such adduct formations may alter protein function and structure providing insights into oxidative modifications of biomolecules. In research settings scientists often use malondialdehyde tests such as the malondialdehyde ELISA kit to quantify MDA levels as a sign of oxidative damage in cells and tissues.

Pathways

Malondialdehyde integrates into the lipid peroxidation pathway. This pathway functions as a feedback loop indicating oxidative stress conditions within cells. Another related pathway includes the arachidonic acid metabolism. MDA formation signals further lipid peroxidation impacting the interaction with several proteins including cyclooxygenases which are involved in inflammation processes.

Malondialdehyde serves as a biomarker for conditions associated with oxidative stress such as cardiovascular diseases and neurodegenerative disorders. Studies have linked elevated MDA levels with cardiovascular diseases where it can interact with low-density lipoproteins marking them for uptake by macrophages. Similarly in neurodegenerative disorders like Alzheimer's malondialdehyde's levels correlate with protein dysfunctions. These are also often observed in conjunction with beta-amyloid interactions contributing to disease pathology. Researchers frequently employ MDA to KDAs in detailed analyses to understand these processes better.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information Malondialdehyde

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文献 (55)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed41009789

2025

Inhibition of HCN Channels Enhances Oxidative Stress and Autophagy of NRK-52E Cells Under NHCl Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Zinaeli López-González,Laura I Escobar,Daniel León-Aparicio,Abirán Fernando Mejía-Peralta,Teresa Padilla-Flores,Isabel Larre,Carolina Salvador,Omar Noel Medina-Campos,José Pedraza-Chaverri,Marisol de la Fuente-Granada

Korean journal of anesthesiology : PubMed40590087

2025

Human placental mesenchymal stem cell-derived exosomes carrying hsa-let-7i-5p mitigate lung injury in a murine model of aspiration pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Ching-Wei Chuang,Hong-Phuc Nguyen Vo,Yen-Hua Huang,I-Lin Tsai,Chao-Yuan Chang,Chun-Jen Huang

Naunyn-Schmiedeberg's archives of pharmacology : PubMed40372476

2025

Therapeutic effect of bismuth subsalicylate in a propionic acid-induced autism model.

Applications

Unspecified application

Species

Unspecified reactive species

Kubilay Doğan Kılıç,Burak Çakar,Yiğit Uyanıkgil,Lora Koenhemsi,Berzah Güneş,Ebru Eroğlu,Oytun Erbaş

PloS one 20:e0313803 PubMed40173155

2025

PM2.5 from automobile exhaust induces apoptosis in male rat germ cells via the ROS-UPRmt signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Cao Wang,Yingchi Zhao,Bin Liu,Zhen Luo,Guangxu Zhou,Kaiyi Mao

Antioxidants (Basel, Switzerland) 13: PubMed39765788

2025

Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Ren Yu,Ching-Yi Tsai,Wei-Ling Chen,Po-Yu Liu,You-Lin Tain,Jiunn-Ming Sheen,Yi-Siang Huang,Mao-Meng Tiao,Chih-Yung Chiu

Antioxidants (Basel, Switzerland) 13: PubMed39765864

2025

Selenium Nanoparticles Suppressed Oxidative Stress and Promoted Tenocyte Marker Expression in Tendon-Derived Stem/Progenitor Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Po Yee Lui,Caihao Huang,Xing Zhang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2400660 PubMed39481440

2024

TGFβ2-Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Su-Jeong Oh,Ye Young Shin,Ji-Su Ahn,Hee-Jeong Park,Min-Jung Kang,Tae-Hoon Shin,Byung-Chul Lee,Won Kyu Kim,Jung-Min Oh,Dongjun Lee,Yun Hak Kim,Ji Min Kim,Eui-Suk Sung,Eun-Woo Lee,Jee-Heon Jeong,Byung-Joo Lee,Yoojin Seo,Hyung-Sik Kim

Nature communications 15:8971 PubMed39420002

2024

Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction.

Applications

Unspecified application

Species

Unspecified reactive species

Chaoyi Xia,Pinghui Peng,Wenxia Zhang,Xiyue Xing,Xin Jin,Jianlan Du,Wanting Peng,Fengqi Hao,Zhexuan Zhao,Kejian Dong,Miaomiao Tian,Yunpeng Feng,Xueqing Ba,Min Wei,Yang Wang

Scientific reports 14:20386 PubMed39223189

2024

SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yutaro Hirashima,Toshiaki Nakano,Kumiko Torisu,Seishi Aihara,Masanori Wakisaka,Takanari Kitazono

Nature communications 15:7337 PubMed39187565

2024

Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Niranjana Natarajan,Jonathan Florentin,Ebin Johny,Hanxi Xiao,Scott Patrick O'Neil,Liqun Lei,Jixing Shen,Lee Ohayon,Aaron R Johnson,Krithika Rao,Xiaoyun Li,Yanwu Zhao,Yingze Zhang,Sina Tavakoli,Sruti Shiva,Jishnu Das,Partha Dutta

View all publications

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Anti-Malondialdehyde抗体

Anti-Malondialdehyde antibody

Western blot - Anti-Malondialdehyde antibody (AB27642)

Western blot - Anti-Malondialdehyde antibody (AB27642)