AB122688

Anti-LRP16抗体

Name: LRP16抗体 (ab122688)| Abcam中文官网
Brand: Abcam Limited
SKU: AB122688
Price: 4606 CNY
Availability: InStock

Anti-LRP16 antibody

(1 Review)

(3 Publications)

Rabbit Polyclonal LRP16 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MACROD1.

查看别名

LRP16, MACROD1, ADP-ribose glycohydrolase MACROD1, MACRO domain-containing protein 1, O-acetyl-ADP-ribose deacetylase MACROD1, Protein LRP16, [Protein ADP-ribosylaspartate] hydrolase MACROD1, [Protein ADP-ribosylglutamate] hydrolase MACROD1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-LRP16 antibody (AB122688)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LRP16 antibody (AB122688)

Immunofluorescent staining of Human cell line A-431 shows positivity in mitochondria. Recommended concentration of ab122688 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP16 antibody (AB122688)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP16 antibody (AB122688)

ab122688, at 1/200 dilution, staining LRP16 in paraffin-embedded Human colon tissue by Immunohistochemistry.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human MACROD1. The exact immunogen used to generate this antibody is proprietary information.

Q9BQ69

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed : 23474712, PubMed : 23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed : 23474712, PubMed : 23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed : 21257746). Plays a role in estrogen signaling (PubMed : 17893710, PubMed : 17914104, PubMed : 19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed : 19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed : 17893710, PubMed : 17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed : 17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed : 17893710). Enhances ESR1-mediated transcription activity (PubMed : 17914104).

See full target information MACROD1

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Polish journal of pathology : official journal of the Polish Society of Pathologists 75:97-104 PubMed39166518

2024

Leukaemia-related protein 16 is highly expressed in oestrogen-dependent endometrial carcinoma and potentially promotes Ishikawa human endometrial cancer cells growth - a histopathological study.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Zhu,Li-Gao Wu,Zhen-Zhong Feng,Qiang Wu

Frontiers in microbiology 9:20 PubMed29410655

2018

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Agnew,Deeksha Munnur,Kerryanne Crawford,Luca Palazzo,Andreja Mikoč,Ivan Ahel

The Journal of biological chemistry 290:16824-40 PubMed25975270

2015

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.

Applications

Unspecified application

Species

Unspecified reactive species

Shaimaa Ahmed,Debbie Bott,Alvin Gomez,Laura Tamblyn,Adil Rasheed,Tiffany Cho,Laura MacPherson,Kim S Sugamori,Yang Yang,Denis M Grant,Carolyn L Cummins,Jason Matthews

View all publications

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Abcam Product Promise

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Anti-LRP16抗体

Anti-LRP16 antibody

Immunocytochemistry/ Immunofluorescence - Anti-LRP16 antibody (AB122688)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP16 antibody (AB122688)