Anti-LMBRD1抗体(ab105419)
Key features and details
- Rabbit polyclonal to LMBRD1
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-LMBRD1抗体 -
描述
兔多克隆抗体to LMBRD1 -
宿主
Rabbit -
特异性
LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
An 18 amino acid peptide from the C-terminus of Human LMBRD1 (NP_060838)
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阳性对照
- Human Brain Tissue Lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105419于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
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| IHC-P |
Use at an assay dependent concentration.
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| 说明 |
|---|
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ICC/IF
Use a concentration of 20 µg/ml. |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa. |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). -
组织特异性
Isoform 3 is expressed in liver. -
疾病相关
Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. -
序列相似性
Belongs to the LIMR family. LMBRD1 subfamily. -
翻译后修饰
N-glycosylated. -
细胞定位
Lysosome membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 55788 Human
- Omim: 612625 Human
- SwissProt: Q9NUN5 Human
- Unigene: 271643 Human
- Unigene: 677072 Human
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别名
- HDAg-L-interacting protein NESI antibody
- LMBD1_HUMAN antibody
- LMBR1 domain-containing protein 1 antibody
see all
图片
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Immunocytochemistry/ Immunofluorescence - Anti-LMBRD1 antibody (ab105419)Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMBRD1 antibody (ab105419)Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.
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Western blot - Anti-LMBRD1 antibody (ab105419)Anti-LMBRD1 antibody (ab105419) at 1 µg/ml + Human brain tissue lysate at 15 µg
Predicted band size: 61 kDa
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab105419 尚未被引用在任何文献中。