Anti-Livin抗体(ab182771)
Key features and details
- Rabbit polyclonal to Livin
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Livin抗体
参阅全部 Livin 一抗 -
描述
兔多克隆抗体to Livin -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human Livin aa 1 to the C-terminus. (BC014475)
Database link: Q96CA5 -
阳性对照
- HeLa and Jurkat cell lysate. Human colon cancer tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab182771于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/2000. Predicted molecular weight: 33 kDa.
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IHC-P |
1/10 - 1/50.
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说明 |
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WB
1/500 - 1/2000. Predicted molecular weight: 33 kDa. |
IHC-P
1/10 - 1/50. |
靶标
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功能
Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. -
组织特异性
Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. -
序列相似性
Belongs to the IAP family.
Contains 1 BIR repeat.
Contains 1 RING-type zinc finger. -
细胞定位
Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 79444 Human
- Omim: 605737 Human
- SwissProt: Q96CA5 Human
- Unigene: 256126 Human
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别名
- Baculoviral IAP repeat containing 7 antibody
- Baculoviral IAP repeat containing protein 7 antibody
- Baculoviral IAP repeat-containing protein 7 antibody
see all
图片
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All lanes : Anti-Livin antibody (ab182771) at 1/300 dilution
Lane 1 : HeLa cell lysate
Lane 2 : Jurkat cell lysate
Lysates/proteins at 40 µg per lane.
Secondary
All lanes : Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Predicted band size: 33 kDaGel: 10% SDS-PAGE
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Immunohistochemistry of paraffin-embedded Human colon cancer tissue labeling Livin using ab182771 at a 1/20 dilution.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab182771 被引用在 1 文献中.
- Gayyed MF & Tawfiek ER Utility of SOX2 and Livin Co-Expression in the Prognosis of Bladder Cancer With Bilharzial and Non-Bilharzial Bladder Status. World J Oncol 6:446-455 (2015). PubMed: 28983346