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AB259508

重组Anti-LEC抗体[EPR21737-212] - BSA and Azide free (Detector)

Anti-LEC antibody [EPR21737-212] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal LEC antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

查看别名

ILINCK, NCC4, SCYA16, CCL16, C-C motif chemokine 16, Chemokine CC-4, Chemokine LEC, IL-10-inducible chemokine, LCC-1, Liver-expressed chemokine, Lymphocyte and monocyte chemoattractant, Monotactin-1, NCC-4, Small-inducible cytokine A16, HCC-4, LMC, MTN-1

1 Images
Sandwich ELISA - Anti-LEC antibody [EPR21737-212] - BSA and Azide free (Detector) (AB259508)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-LEC antibody [EPR21737-212] - BSA and Azide free (Detector) (AB259508)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab243673).

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR21737-212

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

sELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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产品详情

ab259508 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human CCL16. The recommended pair for sandwich ELISA is:
Capture: ab259507, Human CCL16 Capture Antibody (unconjugated)
Detector: ab259508, Human CCL16 Detector Antibody (unconjugated)
The reference range value is 2.34 - 150 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LEC also known as CCL16 is a chemokine protein that functions in the immune system. This protein weighs approximately 22 kDa and resides mainly in the liver and peripheral blood leukocytes. LEC belongs to the CC chemokine family characterized by two adjacent cysteine residues. The protein connects with other cellular systems to modulate immune responses. Antibodies like anti-LEC can detect it effectively and commercial products such as LEC BSA and LEC custom products aid in its study.
Biological function summary

LEC performs vital roles in immune cell signaling and chemotaxis. It binds specifically to certain chemokine receptors on target cells initiating signaling cascades that recruit lymphocytes to infected or inflamed tissues. LEC functions as part of a larger complex that includes other chemokines to coordinate immune responses. Its expression and activity influence various immune functions which makes its regulation significant for maintaining healthy immune system operation.

Pathways

LEC acts within immune signaling pathways and inflammation-related processes. It plays essential parts in pathways like the chemokine signaling pathway where it interacts with other proteins such as CCR1 and CCR2 chemokine receptors. Through these interactions LEC contributes to the recruitment and activation of specific immune cell subtypes facilitating a coordinated response to inflammation or infection.

LEC connects to conditions involving immune dysregulation like rheumatoid arthritis and liver diseases. In rheumatoid arthritis LEC levels can affect inflammation and tissue damage often in concert with proteins like TNF-alpha. In liver diseases altered LEC expression may relate to liver fibrosis with connections to proteins such as TGF-beta. Understanding LEC's role in these conditions can lead to better therapeutic strategies targeting the chemokine network.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
See full target information CCL16
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搭配使用产品

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AB243673

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Recombinant|SimpleStep

Sandwich ELISA - Human CCL16 ELISA Kit (AB243673)

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Primary Antibodies

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