Anti-LDL (Copper oxidized)抗体(ab14519)
Key features and details
- Rabbit polyclonal to LDL (Copper oxidized)
- Suitable for: ELISA, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-LDL (Copper oxidized)抗体 -
描述
兔多克隆抗体to LDL (Copper oxidized) -
宿主
Rabbit -
经测试应用
适用于: ELISA, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Human Cu2+ oxidised LDL.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab14519于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA | ||
IHC-P | (2) |
说明 |
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IHC-P: <1/500.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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相关性
When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease. -
细胞定位
Secreted (probable)
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab14519 被引用在 11 文献中.
- Zha S et al. Topical Simvastatin Improves Lesions of Diffuse Normolipemic Plane Xanthoma by Inhibiting Foam Cell Pyroptosis. Front Immunol 13:865704 (2022). PubMed: 35619689
- Wang P et al. LDL-induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Mol Med Rep 24:N/A (2021). PubMed: 34036387
- Jing J et al. Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells. Cell Death Dis 11:626 (2020). PubMed: 32796811
- Redinus K et al. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight 4:N/A (2019). PubMed: 31391342
- Zhang R et al. FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice. Biomed Res Int 2019:3514574 (2019). PubMed: 31534958