AB14519

Anti-LDL (Copper oxidized)抗体

Anti-LDL (Copper oxidized) antibody

(2 Reviews)

(15 Publications)

Rabbit Polyclonal LDL (Copper oxidized) antibody. Suitable for ELISA, IHC-P and reacts with Human samples. Cited in 15 publications.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, ELISA

applications

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反应性数据

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性能和储存信息

形式

Liquid

纯度

Whole antiserum

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LDL (Copper oxidized) also known as oxidized copper is a type of low-density lipoprotein modified through oxidation processes involving copper ions. LDL with an approximate mass of 2.2 to 3.0 MDa is primarily expressed in the bloodstream and synthesized in the liver. While standard LDL plays a role in lipid transport the oxidized form exhibits altered mechanical properties including greater uptake by macrophages leading to foam cell formation.

Biological function summary

The oxidized form of LDL has a significant role in atherosclerosis progression. Oxidized LDL is not part of a distinct complex but interacts with cells through scavenger receptors like SR-A and CD36 on macrophages prompting inflammatory responses. The oxidative modification occurs when copper ions catalyze the formation of lipid peroxides enhancing the inflammatory potential of LDL.

Pathways

Oxidized LDL acts within the inflammation and lipid metabolism pathways. It contributes to the Toll-like receptor signaling pathway which mediates inflammatory responses and the cholesterol metabolism pathway. Proteins closely related to these pathways include apolipoprotein B-100 which is integral to LDL structure and CEPT an enzyme involved in lipid exchange and transport reactions.

Oxidized LDL has strong associations with atherosclerosis and cardiovascular disease. Its presence in the vascular endothelium induces injury and plaque formation pathways that involve key proteins like matrix metalloproteinases (MMPs) and interleukin-6 (IL-6). Oxidized LDL also links to hyperlipidemia where it exacerbates the risk by promoting endothelial dysfunction and inflammatory signaling creating a feedback loop that further elevates cardiovascular risk.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information LDL (Copper oxidized)

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文献 (15)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6770 PubMed40695827

2025

Metabolism archetype cancer cells induce protumor TREM2 macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tianhao Chu,Guiqi Zhu,Zheng Tang,Weifeng Qu,Rui Yang,Haiting Pan,Yi Wang,Ruilin Tian,Leilei Chen,Zhiqi Guan,Yichao Bu,Qianfu Zhao,Jiafeng Chen,Shengwei Mao,Yuan Fang,Jun Gao,Xiaoling Wu,Jian Zhou,Weiren Liu,Dan Ye,Jia Fan,Yinghong Shi

Pediatric rheumatology online journal 22:73 PubMed39118148

2024

Increased vascular deposition of oxidized LDL in untreated juvenile dermatomyositis.

Applications

Unspecified application

Species

Unspecified reactive species

Jacob C Spitznagle,Akadia Kacha-Ochana,Joan M Cook-Mills,Gabrielle A Morgan,Lauren M Pachman

Experimental hematology & oncology 13:58 PubMed38822440

2024

Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Dongning Rao,Jiaxin Li,Mao Zhang,Siyuan Huang,Lu Meng,Guohe Song,Jiaqiang Ma,Yingcheng Wu,Yifei Cheng,Shuyi Ji,Gaohua Wu,Lv Chen,Yuming Liu,Yang Shi,Jian Zhou,Fan Jia,Xiaoming Zhang,Ruibin Xi,Qiang Gao

Experimental & molecular medicine 54:626-638 PubMed35562586

2022

Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function.

Applications

Unspecified application

Species

Unspecified reactive species

Guo Nan Yin,Do-Kyun Kim,Ji In Kang,Yebin Im,Dong Sun Lee,Ah-Reum Han,Jiyeon Ock,Min-Ji Choi,Mi-Hye Kwon,Anita Limanjaya,Saet-Byel Jung,Jimin Yang,Kwang Wook Min,Jeongwon Yun,Yongjun Koh,Jong-Eun Park,Daehee Hwang,Jun-Kyu Suh,Ji-Kan Ryu,Ho Min Kim

Frontiers in immunology 13:865704 PubMed35619689

2022

Topical Simvastatin Improves Lesions of Diffuse Normolipemic Plane Xanthoma by Inhibiting Foam Cell Pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Zha,Xia Yu,Xiaoxiao Wang,Yan Gu,Yidong Tan,Ying Lu,Zhirong Yao

Molecular medicine reports 24: PubMed34036387

2021

LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Wang,Wenbo Zhang,Zhen Feng,Jian Zhang,Ying Sun,Wei Zhang

Cell death & disease 11:626 PubMed32796811

2020

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Jing,Ning Ding,Dandan Wang,Xie Ge,Jinzhao Ma,Rujun Ma,Xuan Huang,Kadiliya Jueraitetibaike,Kuan Liang,Shuxian Wang,Siyuan Cao,Allan Zijian Zhao,Bing Yao

BioMed research international 2019:3514574 PubMed31534958

2019

FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Zhang,Tingli Wang,Qinhua Yin,Junlin Zhang,Li Li,Ruikun Guo,Qianqian Han,Hanyu Li,Yiting Wang,Jiali Wang,Pramesh Gurung,Yanrong Lu,Jingqiu Cheng,Lin Bai,Jie Zhang,Fang Liu

JCI insight 4: PubMed31391342

2019

An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Redinus,Jin Hyen Baek,Ayla Yalamanoglu,Hye Kyung H Shin,Radu Moldova,Julie W Harral,Delaney Swindle,David Pak,Scott K Ferguson,Rachelle Nuss,Kathryn Hassell,Eva Nozik-Grayck,Andre F Palmer,Mehdi A Fini,Vijaya Karoor,Kurt R Stenmark,Paul W Buehler,David C Irwin

Bioscience reports 38: PubMed29789399

2018

gene polymorphism and its interaction with smoking and drinking on the risk of coronary artery disease for Chinese patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjun Ying,Yuxuan Luo,Hui Peng

View all publications

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Anti-LDL (Copper oxidized)抗体

Anti-LDL (Copper oxidized) antibody