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AB316956

Anti-LCOR 抗体

Anti-LCOR antibody

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Rabbit Polyclonal LCOR antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LCOR.

查看别名

C10orf12, KIAA1795, MLR2, LCOR, Ligand-dependent corepressor, LCoR, Mblk1-related protein 2

1 Images
Western blot - Anti-LCOR Antibody (AB316956)
  • WB

Supplier Data

Western blot - Anti-LCOR Antibody (AB316956)

All lanes:

Western blot - Anti-LCOR Antibody (ab316956) at 4.6 µg/mL

Lane 1:

HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Lane 2:

MCF7 (Human breast adenocarcinoma cell line) whole cell lysate

Lane 3:

A549 (Human lung carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Observed band size: 48 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human LCOR.

Q96JN0

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存条件
-20°C|-80°C
推荐的长期储存条件
-20°C|-80°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LCOR or Ligand-dependent Corepressor serves as a transcriptional corepressor protein playing an integral mechanical role in regulating gene expression. It weighs approximately 66 kDa. Scientists have identified LCOR expression in various tissues including breast lung and liver. The protein interacts with nuclear receptors and transcription factors modulating their activity by silencing gene transcription. Its activity relies on binding to ligand-activated receptors.
Biological function summary

LCOR contributes to the regulation of transcription and modulation of hormone signaling pathways. It operates as a part of a larger multi-protein complex working with other corepressors like NCoR (Nuclear receptor Corepressor) and SMRT (Silencing Mediator of Retinoic acid and Thyroid hormone receptor). This collaboration results in refined control over gene expression particularly in pathways influenced by estrogen and retinoic acid influencing cellular functions such as proliferation and differentiation.

Pathways

LCOR plays a role in significant signaling pathways like estrogen receptor signaling and retinoid metabolism. In these pathways LCOR interacts with proteins such as ERα (Estrogen Receptor alpha) and RXR (Retinoid X Receptor) respectively facilitating the repression of target genes involved in diverse physiological processes. These interactions help modulate cellular responses to hormonal changes further affecting gene transcription profiles.

LCOR is involved in breast cancer and other hormone-dependent malignancies. In breast cancer researchers have found altered LCOR expression linked to disease progression often associated with altered ERα activity. Additionally its interaction with other corepressors like NCoR and SMRT suggests a broader impact on transcriptional dysregulation in these diseases. Understanding LCOR's regulatory role offers potential insights for targeted therapeutic strategies in treating these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
See full target information LCOR
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