AB122223

Anti-LBH抗体

Name: LBH抗体 (ab122223)| Abcam中文官网
Brand: Abcam Limited
SKU: AB122223
Price: 4744 CNY
Availability: InStock

Anti-LBH antibody

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(5 Publications)

Rabbit Polyclonal LBH antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LBH aa 1 to C-terminus.

查看别名

Protein LBH, hLBH, Limb bud and heart development protein homolog, LBH

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human gastrointestinal tissue labelling LBH with ab122223 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling LBH with ab122223 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling LBH with ab122223 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling LBH with ab122223 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Supplier Data

Immunocytochemistry - Anti-LBH antibody (AB122223)

Immunocytochemistry analysis of RH-30 (human bone marrow metastasis cell line) cells labelling LBH with ab122223 at 2 μg/mL.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human LBH aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q53QV2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.25-2 µg/mL", "ICC-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LBH also known as limb-bud and heart protein is a small protein with an approximate mass of 47 kDa. It plays a critical role in cell signaling and development processes by functioning as a transcriptional regulator impacting gene expression. Researchers discovered LBH's expression in several tissues including limb buds the heart and various epithelial tissues. This suggests its involvement in early developmental stages and tissue differentiation.

Biological function summary

LBH influences the development of tissues by modulating gene expression during embryonic growth. It operates as part of a transcriptional complex that interacts with other transcription factors and cofactors. The influence of LBH on cellular differentiation aligns with its expression in developing organs suggesting its role in establishing cellular identities and organogenesis.

Pathways

LBH integrates into signaling pathways related to developmental regulation such as the Wnt signaling pathway and TGF-beta pathway. LBH functions in conjunction with proteins like beta-catenin within the Wnt pathway which is important for cellular proliferation and differentiation. These pathways ensure a coordinated pattern of development linking LBH's activity to broader signaling networks that govern embryogenesis and tissue formation.

Alterations in LBH expression have connections with congenital heart defects and certain cancers illustrating its role in human health. Changes in LBH function or levels may disrupt normal development leading to conditions like atrial septal defects connected to aberrant interactions with transcription factors like T-box proteins. Furthermore its involvement in cancers suggests a link with proteins involved in cell cycle regulation hinting at potential therapeutic targets.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.

See full target information LBH

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:109510 PubMed38660406

2024

The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Anbiao Wu,Chongbin Zhong,Xudong Song,Wen Yuan,Mintian Tang,Tao Shu,Houda Huang,Pingzhen Yang,Qicai Liu

EBioMedicine 48:36-48 PubMed31631037

2019

Overexpression of Limb-Bud and Heart (LBH) promotes angiogenesis in human glioma via VEGFA-mediated ERK signalling under hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Jiang,Jinpeng Zhou,Dan Zou,Dianqi Hou,Haiying Zhang,Junshuang Zhao,Long Li,Jiangfeng Hu,Ye Zhang,Zhitao Jing

PeerJ 7:e6885 PubMed31119084

2019

Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ruoxi Yu,Zhi Li,Chuang Zhang,Huicong Song,Mingming Deng,Liping Sun,Ling Xu,Xiaofang Che,Xuejun Hu,Xiujuan Qu,Yunpeng Liu,Ye Zhang

Cellular physiology and biochemistry : internation 47:223-234 PubMed29788015

2018

Limb-Bud and Heart Attenuates Growth and Invasion of Human Lung Adenocarcinoma Cells and Predicts Survival Outcome.

Applications

Unspecified application

Species

Unspecified reactive species

Mingming Deng,Ruoxi Yu,Shuo Wang,Ye Zhang,Zhi Li,Huicong Song,Bofang Liu,Ling Xu,Ximing Wang,Zhe Zhang,Qingjie Lv,Xiaonan Wang,Xiaofang Che,Xiujuan Qu,Yunpeng Liu,Xuejun Hu

OncoTargets and therapy 11:441-448 PubMed29403288

2018

Overexpression of LBH is associated with poor prognosis in human hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiewei Chen,Chuqiang Huang,Keming Chen,Shuman Li,Xinke Zhang,Jun Cheng,Muyan Cai,Yongbo Xiao

View all publications

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Anti-LBH抗体

Anti-LBH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LBH antibody (AB122223)

Immunocytochemistry - Anti-LBH antibody (AB122223)