Anti-LATS1/WARTS ((phospho T1079) +LATS2 (phospho T1041)抗体(ab111344)
Key features and details
- Rabbit polyclonal to LATS1/WARTS (phospho T1079) + LATS2 (phospho T1041)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-LATS1/WARTS ((phospho T1079) +LATS2 (phospho T1041)抗体 -
描述
兔多克隆抗体to LATS1/WARTS (phospho T1079) + LATS2 (phospho T1041) -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
This product was produced with the following immunogens:
Synthetic peptide corresponding to Human LATS1/WARTS (C terminal) (phospho T1079).
Synthetic peptide corresponding to Human LATS2 (phospho T1041). -
阳性对照
- Human brain tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49.1% PBS, 0.88% Sodium chloride, 50% Glycerol
PBS (without Mg2+ and Ca2+) -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab111344 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111344于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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细胞定位
LATS1/WARTS: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. LATS2: Cytoplasm > cytoskeleton > centrosome. Cytoplasm. Cytoplasm > cytoskeleton > spindle pole. Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. -
数据库链接
- Entrez Gene: 26524 Human
- Entrez Gene: 9113 Human
- Entrez Gene: 16798 Mouse
- Entrez Gene: 50523 Mouse
- Omim: 603473 Human
- Omim: 604861 Human
- SwissProt: O95835 Human
- SwissProt: Q9NRM7 Human
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LATS1/WARTS ((phospho T1079) +LATS2 (phospho T1041) antibody (ab111344)ab111344 at 1/50 dilution staining LATS1 +LATS2 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.
数据表及文件
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SDS download
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Datasheet download
文献 (20)
ab111344 被引用在 20 文献中.
- Meliambro K et al. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight 8:N/A (2023). PubMed: 36853804
- Wang CH et al. Platycodin D confers oxaliplatin Resistance in Colorectal Cancer by activating the LATS2/YAP1 axis of the hippo signaling pathway. J Cancer 14:393-402 (2023). PubMed: 36860929
- Zhang G et al. Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG. Oncol Lett 26:331 (2023). PubMed: 37415630
- Ling Z et al. LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the ß-catenin pathway. Open Med (Wars) 17:453-462 (2022). PubMed: 35350839
- Zhu D et al. RNF43 is a novel tumor-suppressor and prognostic indicator in clear cell renal cell carcinoma. Oncol Res 29:159-174 (2021). PubMed: 37304674