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Immunology Adaptive Immunity T Cells Non-CD

Anti-LAT抗体(ab2507)

  • Datasheet
  • SDS
Submit a review Submit a question References (4)

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Western blot - Anti-LAT antibody (ab2507)

    Key features and details

    • Rabbit polyclonal to LAT
    • Suitable for: WB
    • Reacts with: Mouse, Human
    • Isotype: IgG

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    概述

    • 产品名称

      Anti-LAT抗体
      参阅全部 LAT 一抗
    • 描述

      兔多克隆抗体to LAT
    • 宿主

      Rabbit
    • 特异性

      Binds to a 36-40 Kd protein in normal mouse lung and heart tissue. A larger size band of approx. 40-45 Kd is seen in human tumour cell lines.
    • 经测试应用

      适用于: WBmore details
    • 种属反应性

      与反应: Mouse, Human
    • 免疫原

      Synthetic peptide:

      CHRLPGSYDSTSSDSLYPRGI

      , corresponding to amino acids 29-48 of Human LAT.
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • 存储溶液

      Preservative: 0.1% Sodium azide
      Constituent: 0.1% BSA
    • Concentration information loading...
    • 纯度

      Immunogen affinity purified
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Immunology
      • Adaptive Immunity
      • T Cells
      • Non-CD
      • Signal Transduction
      • Adapters
      • Transmembrane
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • Small G Proteins
      • Ras Family

    相关产品

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • Jurkat whole cell lysate (ab7899)
      • K-562 whole cell lysate (ab7911)
    • Recombinant Protein

      • Recombinant Human LAT protein (ab113124)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab2507于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/1000.
    说明
    WB
    1/1000.

    靶标

    • 功能

      Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
    • 组织特异性

      Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
    • 翻译后修饰

      Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ.
      Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
    • 细胞定位

      Cell membrane. Present in lipid rafts.
    • Target information above from: UniProt accession O43561 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 27040 Human
      • Entrez Gene: 16797 Mouse
      • Omim: 602354 Human
      • SwissProt: O43561 Human
      • SwissProt: O54957 Mouse
      • Unigene: 632179 Human
      • Unigene: 10280 Mouse
      • 别名

        • 36 kDa phospho tyrosine adapter protein antibody
        • 36 kDa phospho-tyrosine adapter protein antibody
        • 36 kDa phospho-tyrosine adaptor protein antibody
        • LAT 1 antibody
        • lat antibody
        • LAT_HUMAN antibody
        • LAT1 antibody
        • Linker for activation of T cells antibody
        • Linker for activation of T cells family member 1 antibody
        • linker for activation of T cells, transmembrane adaptor antibody
        • Linker for activation of T-cells family member 1 antibody
        • p36 38 antibody
        • p36-38 antibody
        • pp36 antibody
        see all

      图片

      • Western blot - Anti-LAT antibody (ab2507)
        Western blot - Anti-LAT antibody (ab2507)
        Antibody recognizes approximately 36 KD size protein and its degradation products in mouse normal tissues. However, antibody specifically reacts with a approximately 46 KD protein in human tumor cell lines Jurkatt and K562. This immunoreactive 46 KD protein appears to be more stable than 36 KD immunoreactive protein observed in normal mouse tissue. (Lane 1, Human T cell line Jurkatt. Lane 2, Mouse Lung Lane 3, Human cell line K562 Lane 4, Mouse Heart).
        Antibody recognizes approximately 36 KD size protein and its degradation products in mouse normal tissues. However, antibody specifically reacts with a approximately 46 KD protein in human tumor cell lines Jurkatt and K562. This immunoreactive 46 KD protein appears to be more stable than 36 KD immunoreactive protein observed in normal mouse tissue. (Lane 1, Human T cell line Jurkatt. Lane 2, Mouse Lung Lane 3, Human cell line K562 Lane 4, Mouse Heart).

      实验方案

      • Western blot protocols
      • Immunocytochemistry & immunofluorescence protocols

      Click here to view the general protocols

      数据表及文件

      • SDS download

      • Datasheet download

        Download

      文献 (4)

      发表研究结果有使用 ab2507?请让我们知道,以便我们可以引用本数据表中的参考文章。

      ab2507 被引用在 4 文献中.

      • Kota DJ  et al. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes 62:2048-58 (2013). WB . PubMed: 23349496
      • Zikherman J  et al. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A 109:E3-12 (2012). WB ; Mouse . PubMed: 22135465
      • Levin SE  et al. Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling. J Biol Chem 283:15419-15430 (2008). WB ; Human . PubMed: 18378687
      • Head BP  et al. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem 281:26391-9 (2006). PubMed: 16818493

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