Anti-Kv1.4/RK3抗体(ab16718)
Key features and details
- Rabbit polyclonal to Kv1.4/RK3
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-Kv1.4/RK3抗体
参阅全部 Kv1.4/RK3 一抗 -
描述
兔多克隆抗体to Kv1.4/RK3 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat, Human
预测可用于: Mouse, Cow
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免疫原
Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Ammonium Sulphate Precipitation -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab16718于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 73 kDa. Detects a band of approximately 76 KDa in HEK293 lysate and 90 kDa in rat hippocampal membranes.
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| 说明 |
|---|
|
WB
Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 73 kDa. Detects a band of approximately 76 KDa in HEK293 lysate and 90 kDa in rat hippocampal membranes. |
靶标
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功能
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. -
序列相似性
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. -
结构域
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 281880 Cow
- Entrez Gene: 3739 Human
- Entrez Gene: 16492 Mouse
- Entrez Gene: 25469 Rat
- Omim: 176266 Human
- SwissProt: Q05037 Cow
- SwissProt: P22459 Human
- SwissProt: Q61423 Mouse
see all -
别名
- Voltage gated K+ channel HuKII antibody
- Fetal skeletal muscle potassium channel antibody
- HBK4 antibody
see all
图片
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Western blot - Anti-Kv1.4/RK3 antibody (ab16718)
Western blots using ab16718.
1: HEK293 cells transfected with Kv1.4/RK3.
2: Rat hippocampal membrane.
The size difference observed can probably be explained by differential post-translational processing.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab16718 被引用在 2 文献中.
- Ying-Wang et al. The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 -/- mice. J Acupunct Meridian Stud 11:88-96 (2018). WB . PubMed: 29608997
- Cho JH et al. Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI Insight 3:N/A (2018). PubMed: 30282820