Anti-Kv1.2抗体(ab55987)
Key features and details
- Rabbit polyclonal to Kv1.2
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-Kv1.2抗体
参阅全部 Kv1.2 一抗 -
描述
兔多克隆抗体to Kv1.2 -
宿主
Rabbit -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
-
免疫原
A synthetic peptide corresponding to C-terminal residues of mouse KCNA2
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab55987于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 1 - 5 µg/ml.
|
| 说明 |
|---|
|
ICC/IF
Use a concentration of 1 - 5 µg/ml. |
靶标
-
相关性
Kv1.2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which K(+) ions may pass in accordance with their electrochemical gradient. Kv1.2 binds PDZ domains of DLG1, DLG2 and DLG4. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. -
细胞定位
Membrane; Multi-pass membrane protein -
数据库链接
- Entrez Gene: 3737 Human
- Entrez Gene: 16490 Mouse
- Entrez Gene: 25468 Rat
- Omim: 176262 Human
- SwissProt: P16389 Human
- SwissProt: P63141 Mouse
- SwissProt: P63142 Rat
-
别名
- Akr6a4 antibody
- BK2 antibody
- HBK5 antibody
see all
图片
-
Immunocytochemistry/ Immunofluorescence - Anti-Kv1.2 antibody - Carboxyterminal end (ab55987)ICC/IF image of ab55987 stained SHSY5Y cells. The cells were 4% formaldehyde fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab55987, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
数据表及文件
-
SDS download
-
Datasheet download
文献 (1)
ab55987 被引用在 1 文献中.
- Zhang C et al. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Exp Ther Med 14:2201-2205 (2017). PubMed: 28962142