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AB181231

重组Anti-KRTAP11-1抗体[EPR13181]

Anti-KRTAP11-1 antibody [EPR13181]

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(1 Publication)

Rabbit Recombinant Monoclonal KRTAP11-1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

KAP11.1, KRTAP11.1, KRTAP11-1, Keratin-associated protein 11-1, High sulfur keratin-associated protein 11.1

1 Images
Western blot - Anti-KRTAP11-1 antibody [EPR13181] (AB181231)
  • WB

Supplier Data

Western blot - Anti-KRTAP11-1 antibody [EPR13181] (AB181231)

All lanes:

Western blot - Anti-KRTAP11-1 antibody [EPR13181] (ab181231) at 1/5000 dilution

All lanes:

Human skin lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab136636'>ab136636</a>) at 1/1000 dilution

Predicted band size: 17 kDa

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关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR13181

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

KRTAP11-1 also known as Keratin-Associated Protein 11-1 is a structural protein with a mass of about 12 kDa. It is part of the family of Keratin-Associated Proteins (KAPs) that play an important role in the architecture of hair fibers. This protein expresses mainly in hair follicles specifically in the cortex and cuticle regions. By binding to keratin proteins KRTAP11-1 contributes to forming the rigid hair structure.
Biological function summary

This protein interacts within the microenvironment of hair follicles to influence hair fiber integrity and rigidity. KRTAP11-1 does not operate within a larger protein complex but its interactions with various keratin types are essential for hair formation and mechanical resilience. Through these interactions it helps control the physicochemical properties of hair impacting characteristics like elasticity and resistance to damage.

Pathways

Research has shown that this protein links to the specialized pathway of hair keratinization which is part of the general epidermis development process. KRTAP11-1 works alongside keratin proteins many of which belong to the type I and type II keratins in this pathway. This interaction supports the orderly assembly and stabilization of the keratin filament network that gives hair its structural integrity.

Studies have associated mutations or irregular expressions of KRTAP11-1 with conditions such as hair disorders like trichothiodystrophy and fragile hair syndrome. These conditions often involve abnormalities in the keratinization process. The protein's relationship with keratin-related proteins may contribute to these disorders when mutations disrupt proper hair structure formation. Such disruptions highlight the importance of understanding KRTAP11-1's role in hair maintenance and formation.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
See full target information KRTAP11-1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 290:14729-39 PubMed25911105

2015

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon.

Applications

Unspecified application

Species

Unspecified reactive species

Qinjie Zhou,Alfonso Lavorgna,Melissa Bowman,John Hiscott,Edward W Harhaj
View all publications
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替代产品

Primary Antibodies

AB222253

Anti-KRTAP11-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRTAP11-1 antibody (AB222253)

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