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Anti-KCNA5/KV1-5抗体(ab110469)

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Western blot - Anti-KCNA5/KV1-5 antibody (ab110469)

    Key features and details

    • Rabbit polyclonal to KCNA5/KV1-5
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    概述

    • 产品名称

      Anti-KCNA5/KV1-5抗体
      参阅全部 KCNA5/KV1-5 一抗

    • 描述

      兔多克隆抗体to KCNA5/KV1-5

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat

    • 免疫原

      Synthetic peptide corresponding to Human KCNA5/KV1-5 (internal sequence).
      Database link: P22460

    • 阳性对照

      • Extracts from 293 cells.

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab110469于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/500 - 1/1000. Predicted molecular weight: 67 kDa.
    说明
    WB
    1/500 - 1/1000. Predicted molecular weight: 67 kDa.

    靶标

    • 功能

      Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.

    • 组织特异性

      Pancreatic islets and insulinoma.

    • 疾病相关

      Defects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.

    • 序列相似性

      Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.

    • 结构域

      The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
      The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    • 翻译后修饰

      Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.

    • 细胞定位

      Membrane.
    • Information by UniProt

    • 数据库链接

      see all

    • 别名

      • ATFB7 antibody
      • cardiac potassium channel antibody
      • HCK1 antibody
      • HK2 antibody
      • HPCN1 antibody
      • insulinoma and islet potassium channel antibody
      • KCNA5 antibody
      • KCNA5_HUMAN antibody
      • KV1.5 antibody
      • PCN1 antibody
      • potassium channel 1 antibody
      • Potassium channel, insulinoma and islet cell antibody
      • Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody
      • Potassium voltage gated channel subfamily A member 5 antibody
      • Potassium voltage-gated channel subfamily A member 5 antibody
      • Voltage-gated potassium channel HK2 antibody
      • voltage-gated potassium channel protein Kv1.5 antibody
      • Voltage-gated potassium channel subunit Kv1.5 antibody
      see all

    图片

    • Western blot - Anti-KCNA5/KV1-5 antibody (ab110469)
      Western blot - Anti-KCNA5/KV1-5 antibody (ab110469)
      All lanes : Anti-KCNA5/KV1-5 antibody (ab110469) at 1/500 dilution

      Lane 1 : Extracts from 293 cells
      Lane 2 : Extracts from 293 cells, treated with synthesized peptide

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 67 kDa

    文献 (1)

    发表研究结果有使用 ab110469？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab110469 被引用在 1 文献中.

    • Xiao Z  et al. MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis. Genes Nutr 17:11 (2022). PubMed: 35858845

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