Anti-KAT7 / Hbo1 / MYST2抗体(ab37289)
Key features and details
- Rabbit polyclonal to KAT7 / Hbo1 / MYST2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-KAT7 / Hbo1 / MYST2抗体
参阅全部 KAT7 / Hbo1 / MYST2 一抗 -
描述
兔多克隆抗体to KAT7 / Hbo1 / MYST2 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human KAT7/ Hbo1/ MYST2 (N terminal).
Database link: O95251 -
常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3692 HAT-2 Antibody. 3692-100 is the same size as the 100 µg size of ab37289.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 1% BSA, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab37289于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).
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说明 |
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WB
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa). |
靶标
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功能
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. -
组织特异性
Ubiquitously expressed, with highest levels in testis. -
序列相似性
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger. -
结构域
The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L.
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Nucleus > nucleoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 11143 Human
- Omim: 609880 Human
- SwissProt: O95251 Human
- Unigene: 21907 Human
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别名
- Hbo 1 antibody
- HBO1 antibody
- HBOa antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab37289 被引用在 3 文献中.
- Ma Y et al. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer. J Radiat Res 64:448-456 (2023). PubMed: 36724120
- Schrötter A et al. FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease. J Cell Sci 126:2480-92 (2013). PubMed: 23572515
- Kueh AJ et al. HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development. Mol Cell Biol 31:845-860 (2011). IHC-P ; Mouse . PubMed: 21149574