AB84140

Anti-KAT13C / NCOA2抗体

Name: KAT13C / NCOA2抗体 (ab84140)| Abcam中文官网
Brand: Abcam Limited
SKU: AB84140
Price: 4606 CNY
Availability: InStock

Anti-KAT13C / NCOA2 antibody

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(1 Publication)

Rabbit Polyclonal KAT13C / NCOA2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NCOA2 aa 1400 to C-terminus.

查看别名

BHLHE75, SRC2, TIF2, NCOA2, Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, Transcriptional intermediary factor 2, bHLHe75, hTIF2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT13C / NCOA2 antibody (AB84140)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT13C / NCOA2 antibody (AB84140)

ab84140, at a 1/100 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
Detection : DAB

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT13C / NCOA2 antibody (AB84140)

ab84140, at a 1/250 dilution, staining KAT13C / NCOA2 in formalin fixed, paraffin embedded human breast adenocarcinoma tissue by Immunohistochemistry.
Detection : DAB

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human NCOA2 aa 1400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15596

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.</p>" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Affinity purified using an epitope specific to KAT13C / NCOA2 immobilized on solid support.

存储溶液

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

KAT13C also known as NCOA2 functions as a transcriptional coactivator involved in nuclear receptor-mediated gene expression. It has a molecular mass of approximately 170 kDa. This protein localizes in the nucleus where it binds with nuclear receptors to enhance transcriptional programming. It is expressed in various tissues including the brain heart and liver indicating its involvement in a diverse range of cellular activities.

Biological function summary

KAT13C/NCOA2 serves as part of a larger protein complex that regulates the expression of target genes following ligand binding to nuclear receptors. It acts as a scaffold protein recruiting additional transcriptional machinery to ensure efficient transcriptional activation. This role is critical for the regulation of hormone-responsive genes and in metabolism cell proliferation and differentiation processes.

Pathways

KAT13C/NCOA2 plays a significant role in the steroid hormone receptor signaling pathway and the nuclear hormone receptor signaling pathway. It interacts with other proteins like p160 family members and the CREB-binding protein (CBP) facilitating coordinated gene expression involved in hormone response and metabolism. These interactions position KAT13C/NCOA2 as an important player in fine-tuning cellular responses to external hormonal signals.

KAT13C/NCOA2 associates with prostate cancer and acute myeloid leukemia. In prostate cancer its interaction with androgen receptor signaling enhances cell proliferation. Meanwhile KAT13C/NCOA2 amplifies gene expression involved in leukemia progression through its interaction with MLL fusion proteins which are implicated in the development of acute myeloid leukemia. These connections underline its role in disease states where abnormal signaling and transcriptional regulation occur.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed : 23508108, PubMed : 8670870, PubMed : 9430642, PubMed : 22504882, PubMed : 26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed : 23508108, PubMed : 8670870, PubMed : 9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed : 23508108, PubMed : 8670870, PubMed : 9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed : 23508108, PubMed : 8670870, PubMed : 9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed : 23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity).

See full target information NCOA2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106314 PubMed37009228

2023

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Simon-Pierre Gravel,Youcef Ben Khalifa,Shawn McGuirk,Catherine St-Louis,Karl M Laurin,Émilie Lavallée,Damien Benas,Stéphanie Desbouis,Frédéric Amaral,Damien D'Amours,Lionel Breton,Sibylle Jäger,Julie St-Pierre

View all publications

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Anti-KAT13C / NCOA2抗体

Anti-KAT13C / NCOA2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT13C / NCOA2 antibody (AB84140)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT13C / NCOA2 antibody (AB84140)