Anti-Kallikrein 11抗体(ab131038)
Key features and details
- Rabbit polyclonal to Kallikrein 11
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Kallikrein 11抗体
参阅全部 Kallikrein 11 一抗 -
描述
兔多克隆抗体to Kallikrein 11 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to a sequence at the C terminal of Human Kallikrein 11.
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阳性对照
- Human prostatic cancer tissue; M231, M453, Jurkat, COLO320 and HT1080 cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Preservatives: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab131038于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 31 kDa.
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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说明 |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 31 kDa. |
IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
靶标
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功能
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. -
组织特异性
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). -
序列相似性
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain. -
翻译后修饰
About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 11012 Human
- Omim: 604434 Human
- SwissProt: Q9UBX7 Human
- Unigene: 57771 Human
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别名
- Hippostasin antibody
- hK11 antibody
- Kallikrein 11 antibody
see all
图片
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All lanes : Anti-Kallikrein 11 antibody (ab131038) at 0.1 µg/ml
Lane 1 : M231 cell lysate
Lane 2 : M453 cell lysate
Lane 3 : Jurkat cell lysate
Lane 4 : COLO320 cell lysate
Lane 5 : HT1080 cell lysate
Lane 6 : COLO320 Cell Lysate
Lane 7 : JURKAT Cell Lysate
Predicted band size: 31 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (ab131038)Immunohistochemical analysis of paraffin-embedded Human prostatic cancer tissue labelling Kallikrein 11 with ab131038 at 0.5 µg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab131038 被引用在 1 文献中.
- Geng X et al. Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. Am J Cancer Res 8:1856-1864 (2018). PubMed: 30323977