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AB252960

Anti-JWA抗体

Anti-JWA antibody

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(1 Publication)

Rabbit Polyclonal JWA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARL6IP5 aa 50-150.

查看别名

DERP11, JWA, PRA2, PRAF3, HSPC127, ARL6IP5, PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL-6-interacting protein 5, Aip-5

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-JWA antibody (AB252960)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-JWA antibody (AB252960)

PFA-fixed, Triton X-100 permeabilized U-251MG (Human brain glioma cell line) cells stained for JWA (green) using ab252960 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JWA antibody (AB252960)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JWA antibody (AB252960)

Paraffin-embedded human duodenum tissue stained for JWA using ab252960 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-JWA antibody (AB252960)
  • WB

Unknown

Western blot - Anti-JWA antibody (AB252960)

All lanes:

Western blot - Anti-JWA antibody (ab252960) at 1/200 dilution

All lanes:

Human cell line RT-4 at 0.4 µg/mL

Predicted band size: 22 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human ARL6IP5 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O75915

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

JWA also known as GTRAP3-18 or ADDCL is a protein with a molecular mass of approximately 37 kDa. Mechanically JWA functions in detoxification processes as it enhances the capacity of cells to combat oxidative stress. This protein exhibits a wide expression pattern across various tissues including the liver and the nervous system. JWA operates in both the cytoplasm and nucleus and dynamically shuttles between these cellular compartments.
Biological function summary

JWA interacts with signaling molecules to modulate cellular responses particularly in stress and repair processes. As a part of multi-protein complexes it collaborates with components like ERK (extracellular signal-regulated kinase) to influence cell survival and proliferation. JWA's involvement extends to regulating cytoskeletal elements affecting cellular movements important for tissue repair and immune responses.

Pathways

JWA integrates into the MAPK/ERK signaling pathway and the ATRA (all-trans retinoic acid) pathway. In these pathways JWA associates with proteins such as MEK1/2 and enhances their activity to promote cell differentiation and combat cellular apoptosis. The interaction of JWA with protein kinases exhibits its integral role in transmitting signaling molecules' instructions necessary for cellular development processes.

JWA shows a connection to cancer and neurodegenerative disorders. In cancer biology JWA's modulation of signaling pathways affects tumor growth interacting with proteins like p53 to induce cell cycle arrest and apoptosis. In the context of neurodegenerative disorders JWA helps mitigate oxidative stress and interacts with proteins involved in neuronal integrity suggesting a protective role against conditions like Alzheimer's disease.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
See full target information ARL6IP5
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6876 PubMed40715139

2025

The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yingchao Xue,Elizabeth Winnicki,Zhaoxu Zhang,Ines Lopez,Saifeng Wang,Charles Kirby,Sam S Lee,Ang Li,Chaewon Lee,Hana Minsky,Kaitlin Williams,Kevin Yueh-Hsun Yang,Ling He,Sashank K Reddy,Luis A Garza
View all publications
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