JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB28837

Anti-JunD抗体

Anti-JunD antibody

5

(1 Review)

|

(10 Publications)

Rabbit Polyclonal JUND antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human Transcription factor jun-D.

查看别名

Transcription factor JunD, Transcription factor AP-1 subunit JunD, JUND

2 Images
Western blot - Anti-JunD antibody (AB28837)
  • WB

Unknown

Western blot - Anti-JunD antibody (AB28837)

All lanes:

Western blot - Anti-JunD antibody (ab28837) at 1/500 dilution

All lanes:

extracts from Hela cells.

Predicted band size: 35 kDa

Observed band size: 43 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JunD antibody (AB28837)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JunD antibody (AB28837)

Immunohistochemical analysis of paraffin embedded human breast carcinoma, using 1/50 JunD Antibody(ab28837).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human Transcription factor jun-D. The exact immunogen used to generate this antibody is proprietary information.

P17535

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column

您是否考虑以下替代产品？

AB181615

Anti-JunD antibody [EPR17365]

3
1 Reviews
查看产品
为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The JunD transcription factor also known as JunD protein belongs to the AP-1 family of transcription factors. It has a mass of approximately 39 kDa. JunD primarily acts by forming dimers with other proteins such as c-Fos and c-Jun. These dimers bind to specific DNA sequences regulating gene expression. JunD shows expression in various tissues but is more abundant in non-dividing and differentiated cells where it helps modulate specific cellular processes.
Biological function summary

JunD plays a significant role by influencing cellular proliferation and differentiation. It is often part of a multiprotein complex which can include members of the Fos family and other Jun proteins. These complexes interact with DNA to control the transcription of genes involved in cell cycle regulation apoptosis and stress responses. Different stimuli can alter the composition of these complexes highlighting JunD's adaptability in cellular signaling.

Pathways

JunD interacts within the MAPK signaling pathway and the oxidative stress response pathway. In the MAPK pathway it can interact with proteins such as ERK and JNK which are critical mediators of cellular responses to growth factors and stress. In the oxidative stress response JunD regulates genes that protect cells from oxidative damage showing its influence on maintaining cellular homeostasis. Other proteins like ATF2 may also interact with JunD within these pathways contributing to transcriptional regulation.

JunD has connections to cancer and neurodegenerative diseases. Its role in regulating cell proliferation links it to tumorigenesis where alterations in its function can lead to uncontrolled cell growth. Additionally in neurodegenerative disorders JunD's influence on oxidative stress response genes may impact disease progression. Furthermore JunD's interaction with the protein Bcl2 associates it with the protection of cells from apoptotic signals illustrating its potential impact on disease development and progression.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Transcription factor binding AP-1 sites (PubMed : 9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed : 28981703, PubMed : 9989505).
See full target information Transcription factor jun-D
style
left-column

文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Circulation research : PubMed32815777

2020

Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD.

Applications

Unspecified application

Species

Unspecified reactive species

Shafaat Hussain,Abdul Waheed Khan,Alexander Akhmedov,Rosa Suades,Sarah Costantino,Francesco Paneni,Kenneth Caidahl,Shafeeq Ahmed Mohammed,Camilla Hage,Christos Gkolfos,Hanna M Björck,John Pernow,Lars H Lund,Thomas F Lüscher,Francesco Cosentino

Medical science monitor : international medical jo 26:e921738 PubMed32672153

2020

Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfeng Sun,Honghua Pan,Shenghui Shen,Zhongni Xia,Zhongmin Yu,ChengLe Li,Pingping Sun,Chuanwei Xin

Cancer medicine 9:5200-5209 PubMed32441484

2020

Identification of the key genes associated with chemotherapy sensitivity in ovarian cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zheng,Meiqin Zhang,Shuang Ma,Wenting Yang,Suhong Xie,Yanchun Wang,Yixuan Liu,Jinyan Kai,Qian Ma,Renquan Lu,Lin Guo

Nature communications 11:1019 PubMed32094355

2020

Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas.

Applications

Unspecified application

Species

Unspecified reactive species

Mthabisi B Moyo,J Brandon Parker,Debabrata Chakravarti

Nature communications 10:4579 PubMed31594926

2019

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Liang,Jie Li,Cheng Lu,Duoli Xie,Jin Liu,Chuanxin Zhong,Xiaohao Wu,Rongchen Dai,Huarui Zhang,Daogang Guan,Baosheng Guo,Bing He,Fangfei Li,Xiaojuan He,Wandong Zhang,Bao-Ting Zhang,Ge Zhang,Aiping Lu

Nature communications 7:12098 PubMed27384883

2016

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41.

Applications

EMSA

Species

Unspecified reactive species

Pierre Bigot,Leandro M Colli,Mitchell J Machiela,Lea Jessop,Timothy A Myers,Julie Carrouget,Sarah Wagner,David Roberson,Caroline Eymerit,Daniel Henrion,Stephen J Chanock

Journal of hematology & oncology 8:120 PubMed26503334

2015

NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin.

Applications

Unspecified application

Species

Human

Dong Suwei,Zeng Liang,Liu Zhimin,Li Ruilei,Zou Yingying,Li Zhen,Ge Chunlei,Lai Zhangchao,Xue Yuanbo,Yang Jinyan,Li Gaofeng,Song Xin

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:13773-83 PubMed26446228

2015

Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew L Eagle,Paula A Gajewski,Miyoung Yang,Megan E Kechner,Basma S Al Masraf,Pamela J Kennedy,Hongbing Wang,Michelle S Mazei-Robison,Alfred J Robison

Carcinogenesis 31:1561-6 PubMed20622002

2010

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.

Applications

WB

Species

Human

Esmerina Tili,Jean-Jacques Michaille,Brett Adair,Hansjuerg Alder,Emeric Limagne,Cristian Taccioli,Manuela Ferracin,Dominique Delmas,Norbert Latruffe,Carlo M Croce

The Journal of endocrinology 203:133-42 PubMed19587266

2009

Genetic background influences embryonic lethality and the occurrence of neural tube defects in Men1 null mice: relevance to genetic modifiers.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel C Lemos,Brian Harding,Anita A C Reed,Jeshmi Jeyabalan,Gerard V Walls,Michael R Bowl,James Sharpe,Sarah Wedden,Julie E Moss,Allyson Ross,Duncan Davidson,Rajesh V Thakker
View all publications
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB134067

Anti-JunD antibody [EPR6520]

primary-antibodies

jund-antibody-epr6520-ab134067

5

(2 reviews)

Alternative Product
Primary Antibodies

AB139180

Anti-JunD (phospho S255) antibody [EPR6461(2)]

primary-antibodies

jund-phospho-s255-antibody-epr64612-ab139180

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com