Anti-JAK3 (phospho Y785)抗体(ab61102)
Key features and details
- Rabbit polyclonal to JAK3 (phospho Y785)
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-JAK3 (phospho Y785)抗体
参阅全部 JAK3 一抗 -
描述
兔多克隆抗体to JAK3 (phospho Y785) -
宿主
Rabbit -
经测试应用
适用于: ELISAmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human JAK3 aa 750-850 (phospho Y785).
Database link: P52333 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab61102于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
ELISA
Use at an assay dependent concentration. |
靶标
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功能
Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. -
组织特异性
In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. -
疾病相关
Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-) SCID) [MIM:600802]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain. -
结构域
Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1. -
翻译后修饰
Tyrosine phosphorylated in response to IL-2 and IL-4. -
细胞定位
Endomembrane system. Wholly intracellular, possibly membrane associated. - Information by UniProt
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数据库链接
- Entrez Gene: 3718 Human
- Entrez Gene: 16453 Mouse
- Entrez Gene: 25326 Rat
- Omim: 600173 Human
- SwissProt: P52333 Human
- SwissProt: Q62137 Mouse
- SwissProt: Q63272 Rat
- Unigene: 515247 Human
see all -
别名
- EC 2.7.10.2 antibody
- JAK 3 antibody
- JAK L antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (5)
ab61102 被引用在 5 文献中.
- Liang Y et al. Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis. Exp Ther Med 22:875 (2021). PubMed: 34194553
- Bradley JR et al. Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma. FASEB Bioadv 2:126-144 (2020). PubMed: 32123862
- Liu B & Ren B MiR-1193 represses the proliferation and induces the apoptosis of interleukin-1ß-treated fibroblast-like synoviocytes via targeting JAK3. Int J Rheum Dis 23:1066-1075 (2020). PubMed: 32597556
- Guo Y et al. Activated janus kinase 3 expression not by activating mutations identified in natural killer/T-cell lymphoma. Pathol Int 64:263-6 (2014). PubMed: 24965108
- Datta R et al. PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model. Allergy 66:853-61 (2011). WB ; Mouse . PubMed: 21276008