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Signal Transduction Signaling Pathway Calcium Signaling Other

Anti-ITPR2抗体(ab5805)

  • Datasheet
  • SDS
Submit a review Submit a question References (4)

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Immunocytochemistry - Anti-ITPR2 antibody (ab5805)
  • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)

Key features and details

  • Rabbit polyclonal to ITPR2
  • Suitable for: ICC, IHC-Fr
  • Reacts with: Rat, Human
  • Isotype: IgG

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概述

  • 产品名称

    Anti-ITPR2抗体
    参阅全部 ITPR2 一抗
  • 描述

    兔多克隆抗体to ITPR2
  • 宿主

    Rabbit
  • 经测试应用

    适用于: ICC, IHC-Frmore details
    不适用于: WB
  • 种属反应性

    与反应: Rat, Human
    预测可用于: Cow
  • 免疫原

    Synthetic peptide corresponding to Rat ITPR2 aa 317-334.
    Sequence:

    ELNPDYRDAQNEGKTVRD


    (Peptide available as ab5842)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • 阳性对照

    • IHC-Fr: Rat brain tissue. ICC: SH-SY5Y cells.
  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • 纯度

    Immunogen affinity purified
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Signal Transduction
    • Signaling Pathway
    • Calcium Signaling
    • Other
    • Cancer
    • Cancer Metabolism
    • Response to hypoxia
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Hypoxia
    • Metabolism
    • Types of disease
    • Cancer

相关产品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab5805于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
ICC
Use a concentration of 2 µg/ml.
IHC-Fr
1/100.
说明
ICC
Use a concentration of 2 µg/ml.
IHC-Fr
1/100.
应用说明
Is unsuitable for WB.

靶标

  • 功能

    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
  • 组织特异性

    Isoform Short is found in skeletal muscle and heart.
  • 疾病相关

    Anhidrosis, isolated, with normal sweat glands
  • 序列相似性

    Belongs to the InsP3 receptor family.
    Contains 5 MIR domains.
  • 结构域

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
  • 翻译后修饰

    Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • 细胞定位

    Endoplasmic reticulum membrane.
  • Target information above from: UniProt accession Q14571 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 281878 Cow
    • Entrez Gene: 3709 Human
    • Entrez Gene: 81678 Rat
    • Omim: 600144 Human
    • SwissProt: Q8WN96 Cow
    • SwissProt: Q14571 Human
    • SwissProt: P29995 Rat
    • Unigene: 512235 Human
    • Unigene: 89152 Rat
    see all
  • 别名

    • 4 antibody
    • 5-trisphosphate receptor antibody
    • Inositol 1 4 5 trisphosphate receptor type 2 antibody
    • Inositol 1,4,5-trisphosphate receptor type 2 antibody
    • Inositol 145 trisphosphate receptor type 2 antibody
    • InsP3 R2 antibody
    • InsP3R2 antibody
    • IP3 R2 antibody
    • IP3 receptor antibody
    • IP3 receptor isoform 2 antibody
    • IP3R 2 antibody
    • IP3R2 antibody
    • ITPR 2 antibody
    • Itpr2 antibody
    • ITPR2_HUMAN antibody
    • Type 2 inositol 1 4 5 trisphosphate receptor antibody
    • Type 2 inositol 1 antibody
    • Type 2 inositol 145 trisphosphate receptor antibody
    • Type 2 InsP3 receptor antibody
    see all

图片

  • Immunocytochemistry - Anti-ITPR2 antibody (ab5805)
    Immunocytochemistry - Anti-ITPR2 antibody (ab5805)

    4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilised SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling ITPR2 using ab5805 at 2 μg/ml in 0.1% BSAfor 3 hours at RT, followed by a Goat Anti-Rabbit (H&L) AlexaFluor® secondary antibody (Green (a)). The nuclear counter stain is DAPI (Blue (b)). F-actin is stained with AlexaFluor® 555-Rhodamine (Red (c)). Panel D shows the merged image. Panel (e) is a secondary antibody only control.

  • Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
    Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
    Shows immunolocalization of IP3R-II in rat brain using ab5805.

实验方案

  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols

Click here to view the general protocols

数据表及文件

  • SDS download

  • Datasheet download

    Download

文献 (4)

发表研究结果有使用 ab5805?请让我们知道,以便我们可以引用本数据表中的参考文章。

ab5805 被引用在 4 文献中.

  • Jaiswal PK  et al. Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Sci Rep 10:7790 (2020). PubMed: 32385306
  • Causton B  et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012
  • Kapoor N  et al. Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. J Physiol 593:2649-63 (2015). PubMed: 25903031
  • Okamoto Y  et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . PubMed: 22285480

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