Anti-ITPR2抗体(ab55981)
Key features and details
- Rabbit polyclonal to ITPR2
- Suitable for: ELISA, WB
- Reacts with: Recombinant fragment
- Isotype: IgG
概述
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产品名称
Anti-ITPR2抗体
参阅全部 ITPR2 一抗 -
描述
兔多克隆抗体to ITPR2 -
宿主
Rabbit -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Recombinant fragment
预测可用于: Mouse, Rat, Human
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免疫原
Synthetic peptide (Human) from a C terminal sequence.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab55981于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 308 kDa.
This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
| 说明 |
|---|
|
ELISA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 308 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
靶标
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功能
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. -
组织特异性
Isoform Short is found in skeletal muscle and heart. -
疾病相关
Anhidrosis, isolated, with normal sweat glands -
序列相似性
Belongs to the InsP3 receptor family.
Contains 5 MIR domains. -
结构域
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. -
翻译后修饰
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3709 Human
- Entrez Gene: 16439 Mouse
- Entrez Gene: 81678 Rat
- Omim: 600144 Human
- SwissProt: Q14571 Human
- SwissProt: Q9Z329 Mouse
- SwissProt: P29995 Rat
- Unigene: 512235 Human
see all -
别名
- 4 antibody
- 5-trisphosphate receptor antibody
- Inositol 1 4 5 trisphosphate receptor type 2 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab55981 被引用在 2 文献中.
- Wu S et al. Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase a2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo. Circulation 139:1913-1936 (2019). PubMed: 30646747
- Kang S et al. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R. Mol Cancer Ther 16:217-227 (2017). PubMed: 28062709