AB197672

Anti-ITGB6抗体

Name: ITGB6抗体 (ab197672)| Abcam中文官网
Brand: Abcam Limited
SKU: AB197672
Price: 4973 CNY
Availability: InStock

Anti-ITGB6 antibody

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(4 Publications)

Rabbit Polyclonal ITGB6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6.

查看别名

Integrin beta-6, ITGB6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6. The exact immunogen used to generate this antibody is proprietary information.

P18564

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein ITGB6 also known as Integrin beta-6 is a part of the integrin family which are transmembrane receptors. ITGB6 has a molecular mass of approximately 88 kDa. It functions mechanically by binding to extracellular matrix proteins such as fibronectin vitronectin and tenascin. ITGB6 pairs exclusively with the integrin alpha-V subunit to form the integrin alpha-V beta-6 (αvβ6) heterodimer. Its expression mainly occurs in epithelial cells particularly in the skin lungs and gastrointestinal tract.

Biological function summary

ITGB6 plays important roles in cell adhesion migration and signaling. It is part of the αv integrin complex which is significant in the regulation of transforming growth factor-beta (TGF-β) activation. This activation influences epithelial-mesenchymal transition (EMT) tissue repair and fibrosis. ITGB6 impacts processes such as inflammation and wound healing due to its expression in epithelial tissues thereby contributing to maintaining tissue integrity and function.

Pathways

ITGB6 interacts in the TGF-β signaling and epithelial cell migration pathways. TGF-β activation via ITGB6 plays a critical role in controlling immune responses and cellular proliferation. ITGB6 is interconnected with other integrin family members such as ITGAV (Integrin alpha-V) which collaborates in cellular mechanisms involving cell adhesion and signaling processes. These interactions contribute to cellular responses to extracellular signals that influence pathophysiological processes.

ITGB6 has associations with fibrosis and cancer. In fibrotic diseases ITGB6 facilitates excess activation of TGF-β leading to aberrant tissue remodeling in organs such as the lungs and liver. Regarding cancer ITGB6 influences tumor progression and metastasis particularly in epithelial-derived cancers due to its role in EMT and tissue invasion. ITGB6's interactions with other integrins and ECM proteins contribute to tumorigenesis and fibrotic tissue changes making it a therapeutic target in these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Integrin alpha-V : beta-6 (ITGAV : ITGB6) is a receptor for fibronectin and cytotactin (PubMed : 17158881, PubMed : 17545607). It recognizes the sequence R-G-D in its ligands (PubMed : 17158881, PubMed : 17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed : 17158881, PubMed : 17545607). ITGAV : ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed : 17158881). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447).. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed : 24367260).

See full target information Integrin beta-6

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0328263 PubMed40680053

2025

Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyue Li,Jie Zhang,Shuang Xiao,Xinyang Liu,Shuai Song,Xiaoyuan Ye,Ruonan Bi,Yuguang Gao,Li Zhang

Journal of biochemical and molecular toxicology 38:e23693 PubMed38622980

2024

IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Ling,Guangbin Ye,Chunyan Qin,Xianjiu Liao,Ruirui Yang,Lili Su,Guangzi Qi

Frontiers in oncology 11:759586 PubMed34976806

2021

Systematic Analysis of an Invasion-Related 3-Gene Signature and Its Validation as a Prognostic Model for Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dafeng Xu,Yu Wang,Yuliang Zhang,Zhehao Liu,Yonghai Chen,Jinfang Zheng

Clinical epigenetics 13:141 PubMed34289901

2021

Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Yuan Feng,Bing-Bing Yan,Yong-Zhi Huang,Li Li

View all publications

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Anti-ITGB6抗体

Anti-ITGB6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)