AB243732

Anti-ITFG2抗体

Name: ITFG2抗体 (ab243732)| Abcam中文官网
Brand: Abcam Limited
SKU: AB243732
Price: 5644 CNY
Availability: InStock

Anti-ITFG2 antibody

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal ITFG2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KICSTOR complex protein ITFG2 aa 200-350.

查看别名

KICSTOR complex protein ITFG2, Integrin-alpha FG-GAP repeat-containing protein 2, ITFG2

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-ITFG2 antibody (AB243732)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ITFG2 antibody (AB243732)

PFA fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells labeling ITFG2 using ab243732 at 4 μg/ml (green) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITFG2 antibody (AB243732)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITFG2 antibody (AB243732)

Formalin-fixed, paraffin-embedded human colon tissue stained for ITFG2 with ab243732 at a 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-ITFG2 antibody (AB243732)

All lanes:

Western blot - Anti-ITFG2 antibody (ab243732) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate

Lane 2:

ITFG2 overexpression HEK-293T cell lysate

Predicted band size: 49 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human KICSTOR complex protein ITFG2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q969R8

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein ITFG2 or Integrin Alpha FG-GAP Repeat Containing 2 plays an essential role in cell adhesion and migration mechanisms. Its molecular mass is approximately 42 kDa. Researchers have identified ITFG2 expression in various tissues including the heart brain liver and skeletal muscle indicating its potential involvement in diverse physiological processes.

Biological function summary

ITFG2 contributes to cell-cell interaction and signaling. It acts as part of the integrin protein family which facilitates communication between cells and their surrounding environment. The protein participates in processes involving cell adhesion through forming complexes with other integrins influencing cellular responses. ITFG2 by interacting with other cellular components supports the maintenance of cell structure and tissue architecture.

Pathways

ITFG2's function integrates into significant biological pathways notably the integrin-mediated signaling pathway and focal adhesion pathway. These pathways involve cooperation with other proteins like integrin beta subunits which assist in transmitting signals that affect cell proliferation survival and differentiation. ITFG2's contribution to these pathways highlights its involvement in essential cellular events and homeostasis.

ITFG2 is linked to certain pathological conditions due to its role in cellular communication. Abnormal expression of ITFG2 has been associated with cancer progression as it may alter cell adhesion properties promoting metastasis. Additionally researchers are investigating its connection to cardiovascular diseases given its expression in heart tissue and interaction with integrin-related proteins in these contexts. Understanding ITFG2's function may therefore provide insights into therapeutic strategies for these conditions.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

See full target information KICSTOR complex protein ITFG2

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Placenta 160:118-125 PubMed39793469

2025

Placental alkaline phosphatase (PLAP): Is it exclusively placental?

Applications

Unspecified application

Species

Unspecified reactive species

Awanit Kumar,Sourabh Sharma,Maged M Costantine,Kara Rood,Rheanna Urrabaz-Garza,Jeena Jacob,Lauren S Richardson,Ananth Kumar Kammala,Ramkumar Menon

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITFG2抗体

Anti-ITFG2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ITFG2 antibody (AB243732)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITFG2 antibody (AB243732)

Western blot - Anti-ITFG2 antibody (AB243732)