Anti-IRSp53抗体- C-terminal
Anti-IRSp53 antibody - C-terminal
4
(1 Review)
|
(4 Publications)
Goat Polyclonal IRSp53 antibody. C-terminal. Suitable for WB and reacts with Human, Mouse, Dog samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human Brain-specific angiogenesis inhibitor 1-associated protein 2 aa 500-550.
查看别名
BAR/IMD domain-containing adapter protein 2, Brain-specific angiogenesis inhibitor 1-associated protein 2, Fas ligand-associated factor 3, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2, FLAF3, IRS-58, IRSp53/58, IRSp53, Insulin receptor substrate p53, BAIAP2
- WB
Unknown
Western blot - Anti-IRSp53 antibody - C-terminal (AB15697)
ab15697 staining (1μg/ml) of human brain lysate (RIPA buffer, 35μg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
All lanes:
Western blot - Anti-IRSp53 antibody - C-terminal (ab15697) at 1 µg/mL
All lanes:
Lysates prepared from human brain at 35 µg
Predicted band size: 61 kDa
false
反应性数据
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性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
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分装信息
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补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IRSp53 participates in the modulation of cell shape and motility. It is a component of the protein complexes that couple membrane dynamics to cytoskeleton remodeling. Through its interaction with proteins like CDC42 and Rac1 IRSp53 guides the rearrangement of actin filaments affecting cell movement and shape. These abilities make it significant for cellular processes requiring changes in cell structure such as neurodevelopment and wound healing.
Pathways
IRSp53 is central to the regulation of cell motility pathways and signaling processes. It plays an important role in the WAVE (WASP family verprolin-homologous protein) regulatory complex which influences actin polymerization. The protein interacts with Rac1 and N-WASP to mediate pathways leading to the formation of actin-rich structures. This modulation of actin dynamics links IRSp53 to the broader MAPK/ERK signaling pathway impacting cellular proliferation and differentiation.
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靶点信息
文献 (4)
Recent publications for all applications. Explore the full list and refine your search
eLife 13: PubMed40548551
2025
Applications
Unspecified application
Species
Unspecified reactive species
eLife 9: PubMed32975518
2020
Applications
Unspecified application
Species
Unspecified reactive species
Molecular cell 55:436-50 PubMed25042806
2014
Applications
Unspecified application
Species
Unspecified reactive species
The Journal of cell biology 192:525-40 PubMed21282462
2011
Applications
WB
Species
Dog
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