Anti-IRF6抗体[OTI2A12]
Anti-IRF6 antibody [OTI2A12]
3
(1 Review)
|
(4 Publications)
Mouse Monoclonal IRF6 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, African green monkey, Transfected cell line samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IRF6.
查看别名
Interferon regulatory factor 6, IRF-6, IRF6
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody [OTI2A12] (AB123880)
Paraffin-embedded human kidney tissue stained for IRF6 using ab123880 at 1/150 dilution in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody [OTI2A12] (AB123880)
Paraffin-embedded human endometrium adenocarcinoma tissue stained for IRF6 using ab123880 at 1/150 dilution in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody [OTI2A12] (AB123880)
Paraffin-embedded human colon adenocarcinoma tissue stained for IRF6 using ab123880 at 1/150 dilution in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody [OTI2A12] (AB123880)
Paraffin-embedded human lung carcinoma tissue stained for IRF6 using ab123880 at 1/150 dilution in immunohistochemical analysis.
- Flow Cyt (Intra)
Unknown
Flow Cytometry (Intracellular) - Anti-IRF6 antibody [OTI2A12] (AB123880)
Flow cytometric analysis of HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cells transfected with either pCMV6-ENTRY IRF6 overexpress plasmid (Red), or empty vector control plasmid (Blue).
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-IRF6 antibody [OTI2A12] (AB123880)
COS-7 (African green monkey kidney fibroblast-like cell line) cells transiently transfected using pCMV6-ENTRY IRF6 stained for IRF6 (green) in ICC/IF.
- WB
Unknown
Western blot - Anti-IRF6 antibody [OTI2A12] (AB123880)
All lanes:
Western blot - Anti-IRF6 antibody [OTI2A12] (ab123880) at 1/2000 dilution
Lane 1:
HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cells transfected with pCMV6-ENTRY control cDNA at 5 µg
Lane 2:
HEK-293T cells transfected with pCMV6-ENTRY IRF6 cDNA at 5 µg
Predicted band size: 53 kDa
false
反应性数据
性能和储存信息
形式
纯化工艺
纯化说明
存储溶液
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IRF6 orchestrates various cellular activities essential for tissue development and repair. It functions as a transcriptional activator influencing the expression of genes involved in the morphogenesis of craniofacial structures. IRF6 does not form large protein complexes but rather exerts its function through interaction with DNA and possibly with other transcription factors. It contributes to epithelial differentiation and proliferation balancing growth and apoptosis in tissues.
Pathways
IRF6 participates significantly in the Wnt and Notch signaling pathways. Both pathways are critical for regulating cell fate and development processes. The Notch pathway influences differentiation in the epithelial cells while the Wnt pathway is key for controlling the balance between growth and differentiation. IRF6 interacts with proteins such as RIPK4 which mediates signaling important for preventing excessive proliferation by promoting differentiation processes.
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靶点信息
文献 (4)
Recent publications for all applications. Explore the full list and refine your search
Cancer cell international 25:191 PubMed40413506
2025
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 43:1092-1102 PubMed37946471
2023
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Species
Unspecified reactive species
Cancer cell international 21:246 PubMed33941190
2021
Applications
Unspecified application
Species
Unspecified reactive species
Vaccines 8: PubMed32046307
2020
Applications
Unspecified application
Species
Unspecified reactive species
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