AB275609

Anti-IRF6抗体

Name: IRF6抗体 (ab275609)| Abcam中文官网
Brand: Abcam Limited
SKU: AB275609
Price: 4863 CNY
Availability: InStock

Anti-IRF6 antibody

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Rabbit Polyclonal IRF6 antibody. Carrier free. Suitable for IHC-P, ICC/IF and reacts with Mouse, African green monkey samples. Immunogen corresponding to Synthetic Peptide within Mouse Interferon regulatory factor 6.

查看别名

Interferon regulatory factor 6, IRF-6, Irf6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody (AB275609)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody (AB275609)

Immunohistochemical analysis of paraffin embedded mouse small intestine labeling IRF6 with ab275609 at 1/1000 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-IRF6 antibody (AB275609)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-IRF6 antibody (AB275609)

Immunocytochemical analysis of COS-7 (African green monkey kidney fibroblast-like cell line) cells labeling IRF6 with ab275609 at 1/1000 dilution at 4℃ overnight, followed by Goat Anti-rabbit IgG Alexa Fluor®488-conjugated secondary antibody (green). Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum prior incubation with ab275609. Positive staining was localized to cytoplasm and nucleus.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Mouse, African green monkey

应用

IHC-P, ICC/IF

applications

免疫原

Synthetic Peptide within Mouse Interferon regulatory factor 6. The exact immunogen used to generate this antibody is proprietary information.

P97431

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "African green monkey": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/300 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Interferon Regulatory Factor 6 (IRF6) is a transcription factor known for its role in the regulation of gene expression involved in developmental processes. It weighs approximately 53 kDa and it is part of the IRF family of transcription factors. This protein is predominantly found in the epithelial tissues where it plays a critical role in keratinocyte differentiation and proliferation. The expression of IRF6 can be observed in several tissues but it is especially important in the oral epithelium skin and hair follicles.

Biological function summary

IRF6 orchestrates various cellular activities essential for tissue development and repair. It functions as a transcriptional activator influencing the expression of genes involved in the morphogenesis of craniofacial structures. IRF6 does not form large protein complexes but rather exerts its function through interaction with DNA and possibly with other transcription factors. It contributes to epithelial differentiation and proliferation balancing growth and apoptosis in tissues.

Pathways

IRF6 participates significantly in the Wnt and Notch signaling pathways. Both pathways are critical for regulating cell fate and development processes. The Notch pathway influences differentiation in the epithelial cells while the Wnt pathway is key for controlling the balance between growth and differentiation. IRF6 interacts with proteins such as RIPK4 which mediates signaling important for preventing excessive proliferation by promoting differentiation processes.

IRF6 mutations link to conditions such as Van der Woude syndrome and orofacial clefting which involve developmental anomalies in facial structures. These mutations may disrupt normal protein function impacting critical pathways and their downstream effects. IRF6 dysfunction in these disorders may also involve interactions with other proteins like p63 influencing epithelial development negatively and contributing to the clinical manifestations observed in these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.

See full target information Interferon regulatory factor 6

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Anti-IRF6抗体

Anti-IRF6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF6 antibody (AB275609)

Immunocytochemistry/ Immunofluorescence - Anti-IRF6 antibody (AB275609)