AB204225

Anti-IQGAP2抗体

Name: IQGAP2抗体 (ab204225)| Abcam中文官网
Brand: Abcam Limited
SKU: AB204225
Price: 4606 CNY
Availability: InStock

Anti-IQGAP2 antibody

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(1 Publication)

Rabbit Polyclonal IQGAP2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Ras GTPase-activating-like protein IQGAP2 aa 500-650.

查看别名

Ras GTPase-activating-like protein IQGAP2, IQGAP2

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-IQGAP2 antibody (AB204225)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IQGAP2 antibody (AB204225)

Immunofluorescence analysis of parafolmaldehyde-fixed, Triton X-100 permelized CACO 2 cells labeling IQGAP2 using ab204225 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IQGAP2 antibody (AB204225)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IQGAP2 antibody (AB204225)

Immunohistochemical analysis of paraffin-embedded Human pancreas tissue, labeling IQGAP2 using ab204225 at a 1/500 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human Ras GTPase-activating-like protein IQGAP2 aa 500-650. The exact immunogen used to generate this antibody is proprietary information.

Q13576

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

IQGAP2 also known as Ras GTPase-activating-like protein IQGAP2 is a protein involved in intracellular signaling and the dynamics of the cytoskeleton. The molecular mass of IQGAP2 is approximately 180 kDa. It is expressed in various tissues with significant expression levels observed in the liver and stomach. IQGAP2 functions as a scaffold protein interacting with numerous cellular components to modulate their activities.

Biological function summary

IQGAP2 influences several cellular processes including cell adhesion migration and signaling pathways. It interacts with actin filaments and participates in the Rac1 signaling complex. By binding with calmodulin and other partners IQGAP2 regulates the cytoskeletal architecture contributing to cellular morphology and movement. Through its involvement in cellular interactions IQGAP2 plays roles in both normal physiological functions and pathological conditions.

Pathways

IQGAP2 participates in the MAPK and Wnt signaling pathways. In these pathways it interacts with proteins like beta-catenin and ERK influencing signal transduction that affects cell growth and differentiation. IQGAP2's role in these pathways demonstrates its significance in regulating cellular responses to environmental cues and its impact on developmental processes and tissue homeostasis.

IQGAP2's dysfunction associates with cancer particularly hepatocellular carcinoma and gastric cancer. Its interaction with beta-catenin and E-cadherin links it to the pathways that influence tumorigenesis and cancer cell adhesion. Variations in IQGAP2 expression or activity can disrupt cellular architecture and signaling contributing to disease progression and metastasis in these malignancies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

See full target information Ras GTPase-activating-like protein IQGAP2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 15: PubMed37046668

2023

Reticulocalbin 3 Is a Novel Mediator of Glioblastoma Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yi He,Salvador Alejo,Jessica D Johnson,Sridharan Jayamohan,Gangadhara R Sareddy

View all publications

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Anti-IQGAP2抗体

Anti-IQGAP2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-IQGAP2 antibody (AB204225)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IQGAP2 antibody (AB204225)