JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB69927

Anti-IQ motif containing B1抗体

Anti-IQ motif containing B1 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Mouse Polyclonal IQ motif containing B1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IQCB1.

查看别名

KIAA0036, NPHP5, OK/SW-cl.85, IQCB1, IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein, PIQ

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human IQCB1.

Q15051

style
left-column

替代产品

Primary Antibodies

AB241197

Anti-IQ motif containing B1 antibody

Immunoprecipitation - Anti-IQ motif containing B1 antibody (AB241197)

  • 0
  • 0

搭配使用产品

Proteins & Peptides

AB160598

Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human IQ motif containing B1 protein (GST tag N-Terminus) (AB160598)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p>Predicted molecular weight for isoform 2: 54 kDa.</p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

IQ motif containing B1 also known as IQCB1 or NPHP5 is a protein that functions mechanically as a part of cellular pathways involving microtubule dynamics. This protein has an approximate mass of 69 kDa and is widely expressed in various tissues with higher levels noted in the retina and kidney. The function of IQCB1 is closely related to its role in intracellular transport and sensory cilia signaling.
Biological function summary

IQ motif containing B1 plays an important role in the ciliary transition zone which is an important component in cilia formation and function. This protein is part of a protein complex known as the nephronophthisis module where it collaborates with other proteins to maintain ciliary structural integrity. Defects or mutations in IQCB1 may disrupt this module highlighting its significance in normal cellular operations.

Pathways

The IQ motif containing B1 is involved in the ciliogenesis and cilia function pathways. In these pathways it interacts with proteins such as NPHP6 (also known as CEP290) to regulate ciliary assembly and ensure proper signal transduction. IQCB1's function is essential for the proper maintenance of these pathways which are critical for sensory perception and cellular communication.

Mutations in IQ motif containing B1 are linked to conditions such as nephronophthisis and retinitis pigmentosa. The protein's interaction with other proteins like RPGR which is associated with retinitis pigmentosa emphasizes its role in multi-systemic diseases affecting the kidneys and eyes. Understanding the function and interaction of IQCB1 with these proteins provides insights into the mechanisms underlying these disorders and may guide future therapeutic strategies.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed : 21565611, PubMed : 23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed : 25552655).
See full target information IQCB1
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 77:195-212 PubMed31177295

2019

Requirement of NPHP5 in the hierarchical assembly of basal feet associated with basal bodies of primary cilia.

Applications

Unspecified application

Species

Unspecified reactive species

Delowar Hossain,Marine Barbelanne,William Y Tsang

Human molecular genetics 23:40-51 PubMed23943788

2013

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhang,Seongjin Seo,Sajag Bhattarai,Kevin Bugge,Charles C Searby,Qihong Zhang,Arlene V Drack,Edwin M Stone,Val C Sheffield
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com